日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition.

Angelman 综合征的临床前猪模型反映了人类疾病的早期发展轨迹

Myers Luke S, Christian Sarah G, Simpson Sean, Sper Renan, Taylor Clint, Montes Laura, Jepp Thomas B C, Ramos Daniela, Schuller Livia, Konganti Kranti, Friedeck Wade, Habib Ozair, Hodge McKaela, Taylor Alasdair J, Coffell Ashley, Schlafer Annalise, Matt Morgan, Revell Bradley, Knight Carol, Barreña Cristina C, Murphy William J, Weeber Edwin J, Segal David J, Anderson Anne, Nash Kevin R, Silverman Jill L, Piedrahita Jorge A, Dindot Scott V

Adeno-Associated Viral Gene Delivery of Wild-Type Human Tau Induces Progressive Hyperphosphorylation and Neuronal Cell Death in the Hippocampi of Middle-Aged Rats.

腺相关病毒基因递送野生型人类 Tau 可诱导中年大鼠海马体进行性过度磷酸化和神经元细胞死亡

Gorzek Ryan C, Joly-Amado Aurelie, Hurst-Calle Natalia, Gabrielson Graham L, Miller Maxine, Osting Sue, Nash Kevin R, Burger Corinna

Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy

在两种tau蛋白病小鼠模型中,干扰白细胞介素-1受体信号传导并不能改善成熟的tau蛋白病理。

Finneran, Dylan J; Jackman, Brianna M; Desjarlais, Taylor; Henry, Alayna; Soliman, Ahlam S; Muskus, Patricia C; Shankar, Rama; Chen, Bin; Nash, Kevin R; Morgan, Dave; Gordon, Marcia N

A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus.

早期散发性 tau 病理的小鼠模型可诱导海马体神经源性可塑性。

Ash Alyssa M, Baek Sue Rim, Holder Peyton, Singh Sara, Vyleta Nicholas P, Willman Matthew, Nash Kevin R, Snyder Jason S

Adenylyl cyclase 2 expression and function in neurological diseases

腺苷酸环化酶 2 在神经系统疾病中的表达和功能

Gray, Marsilla; Nash, Kevin R; Yao, Yao

Evaluating the Efficacy of Levetiracetam on Non-Cognitive Symptoms and Pathology in a Tau Mouse Model

评估左乙拉西坦对Tau蛋白小鼠模型非认知症状和病理的疗效

Thompson, Jackson C; Levis Rabi, Marselina; Novoa, Michelle; Nash, Kevin R; Joly-Amado, Aurelie

Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases

Reelin信号通路在神经发育障碍和神经退行性疾病中的作用

Joly-Amado, Aurelie; Kulkarni, Neel; Nash, Kevin R

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

构建一种具有完全Ube3a基因缺失的新型Angelman综合征大鼠模型

Dodge, Andie; Peters, Melinda M; Greene, Hayden E; Dietrick, Clifton; Botelho, Robert; Chung, Diana; Willman, Jonathan; Nenninger, Austin W; Ciarlone, Stephanie; Kamath, Siddharth G; Houdek, Pavel; Sumová, Alena; Anderson, Anne E; Dindot, Scott V; Berg, Elizabeth L; O'Geen, Henriette; Segal, David J; Silverman, Jill L; Weeber, Edwin J; Nash, Kevin R

Neuroinflammation and fractalkine signaling in Alzheimer's disease

阿尔茨海默病中的神经炎症和趋化因子信号传导

Finneran, Dylan J; Nash, Kevin R

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

组蛋白去乙酰化酶6抑制剂可改善小鼠tau蛋白沉积模型中的记忆力并降低总tau蛋白水平。

Selenica, Maj-Linda; Benner, Leif; Housley, Steven B; Manchec, Barbara; Lee, Daniel C; Nash, Kevin R; Kalin, Jay; Bergman, Joel A; Kozikowski, Alan; Gordon, Marcia N; Morgan, Dave