日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

CYP27A1 依赖的柠檬苦素类天然产物的抗黑色素瘤活性靶向线粒体代谢

Hyelim Cho, Qiong Shen, Lydia H Zhang, Mikiko Okumura, Akinori Kawakami, Jessi Ambrose, Frederic Sigoillot, Howard R Miller, Scott Gleim, Amanda Cobos-Correa, Ying Wang, Philippe Piechon, Guglielmo Roma, Fabian Eggimann, Charles Moore, Peter Aspesi Jr, Felipa A Mapa, Heather Burks, Nathan T Ross, Ph

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma

CPSF3依赖性前体mRNA加工是急性髓系白血病和尤文氏肉瘤中可作为药物靶点的节点

Nathan T Ross # ,Felix Lohmann # ,Seth Carbonneau ,Aleem Fazal ,Wilhelm A Weihofen ,Scott Gleim ,Michael Salcius ,Frederic Sigoillot ,Martin Henault ,Sarah H Carl ,Juan B Rodríguez-Molina ,Howard R Miller ,Scott M Brittain ,Jason Murphy ,Mark Zambrowski ,Geoffrey Boynton ,Yuan Wang ,Aye Chen ,Gregory J Molind ,Johannes H Wilbertz ,Caroline G Artus-Revel ,Min Jia ,Favour A Akinjiyan ,Jonathan Turner ,Judith Knehr ,Walter Carbone ,Sven Schuierer ,John S Reece-Hoyes ,Kevin Xie ,Chitra Saran ,Eric T Williams ,Guglielmo Roma ,Matt Spencer ,Jeremy Jenkins ,Elizabeth L George ,Jason R Thomas ,Gregory Michaud ,Markus Schirle ,John Tallarico ,Lori A Passmore ,Jeffrey A Chao ,Rohan E J Beckwith #

A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling

巨噬细胞中的高内涵筛选可鉴定出 STING-IRF3 和 NFkB 信号的小分子调节剂

Peter D Koch, Howard R Miller, Gary Yu, John A Tallarico, Peter K Sorger, Yuan Wang, Yan Feng, Jason R Thomas, Nathan T Ross, Timothy Mitchison

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex

Ternatin 及其改良的合成变体通过靶向延伸因子-1A 三元复合物杀死癌细胞

Jordan D Carelli, Steven G Sethofer, Geoffrey A Smith, Howard R Miller, Jillian L Simard, William C Merrick, Rishi K Jain, Nathan T Ross, Jack Taunton

Identification of small molecules for human hepatocyte expansion and iPS differentiation

鉴定用于人类肝细胞扩增和iPS分化的小分子

Jing Shan, Robert E Schwartz, Nathan T Ross, David J Logan, David Thomas, Stephen A Duncan, Trista E North, Wolfram Goessling, Anne E Carpenter, Sangeeta N Bhatia

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

一种多模式RAGE特异性抑制剂可减轻阿尔茨海默病小鼠模型中淀粉样β蛋白介导的脑部疾病

Rashid Deane,Itender Singh, Abhay P Sagare, Robert D Bell, Nathan T Ross, Barbra LaRue, Rachal Love, Sheldon Perry, Nicole Paquette, Richard J Deane, Meenakshisundaram Thiyagarajan, Troy Zarcone, Gunter Fritz, Alan E Friedman, Benjamin L Miller, Berislav V Zlokovic

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

强效且选择性的喹喔啉酮类 STK33 抑制剂在 KRAS 依赖性细胞中未表现出合成致死性

Michel Weïwer, James Spoonamore, Jingqiang Wei, Boris Guichard, Nathan T Ross, Kristina Masson, Whitney Silkworth, Sivaraman Dandapani, Michelle Palmer, Christina A Scherer, Andrew M Stern, Stuart L Schreiber, Benito Munoz

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability

STK33 激酶抑制剂 BRD-8899 对 KRAS 依赖性癌细胞活力无影响

Tuoping Luo, Kristina Masson, Jacob D Jaffe, Whitney Silkworth, Nathan T Ross, Christina A Scherer, Claudia Scholl, Stefan Fröhling, Steven A Carr, Andrew M Stern, Stuart L Schreiber, Todd R Golub