日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

PTPN2/PTPN1抑制剂ABBV-CLS-484可释放强大的抗肿瘤免疫力。

Christina K Baumgartner # ,Hakimeh Ebrahimi-Nik # ,Arvin Iracheta-Vellve ,Keith M Hamel ,Kira E Olander ,Thomas G R Davis ,Kathleen A McGuire ,Geoff T Halvorsen ,Omar I Avila ,Chirag H Patel ,Sarah Y Kim ,Ashwin V Kammula ,Audrey J Muscato ,Kyle Halliwill ,Prasanthi Geda ,Kelly L Klinge ,Zhaoming Xiong ,Ryan Duggan ,Liang Mu ,Mitchell D Yeary ,James C Patti ,Tyler M Balon ,Rebecca Mathew ,Carey Backus ,Domenick E Kennedy ,Angeline Chen ,Kenton Longenecker ,Joseph T Klahn ,Cara L Hrusch ,Navasona Krishnan ,Charles W Hutchins ,Jax P Dunning ,Marinka Bulic ,Payal Tiwari ,Kayla J Colvin ,Cun Lan Chuong ,Ian C Kohnle ,Matthew G Rees ,Andrew Boghossian ,Melissa Ronan ,Jennifer A Roth ,Meng-Ju Wu ,Juliette S M T Suermondt ,Nelson H Knudsen ,Collins K Cheruiyot ,Debattama R Sen ,Gabriel K Griffin ,Todd R Golub ,Nabeel El-Bardeesy ,Joshua H Decker ,Yi Yang ,Magali Guffroy ,Stacey Fossey ,Patricia Trusk ,Im-Meng Sun ,Yue Liu ,Wei Qiu ,Qi Sun ,Marcia N Paddock ,Elliot P Farney ,Mark A Matulenko ,Clay Beauregard ,Jennifer M Frost # ,Kathleen B Yates # ,Philip R Kym # ,Robert T Manguso #

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

在新型 C 末端位点鉴定和基于结构的白细胞介素 17A 细胞活性抑制剂的药物设计

Eric R Goedken, Maria A Argiriadi, Justin D Dietrich, Andrew M Petros, Navasona Krishnan, Sanjay C Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M Adams, Pierre M Bodelle, Lucas Goguen, Paul L Richardson, Peter F Slivka, Myron Srikumaran, Anup K Upadhyay, Bainan Wu, Russell A Judge, Anil Vasude

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

利用胰岛素和瘦素诱导的 PTP1B 氧化进行治疗开发

Navasona Krishnan, Christopher A Bonham, Ioana A Rus, Om Kumar Shrestha, Carla M Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K Tonks

DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease

DPM-1001降低了小鼠威尔逊病模型中的铜水平并改善了其功能缺陷。

Krishnan, Navasona; Felice, Christy; Rivera, Keith; Pappin, Darryl J; Tonks, Nicholas K

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

PTP1B 抑制提示了 Rett 综合征的治疗策略

Navasona Krishnan, Keerthi Krishnan, Christopher R Connors, Meng S Choy, Rebecca Page, Wolfgang Peti, Linda Van Aelst, Stephen D Shea, Nicholas K Tonks

A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells

新型磷脂酸-蛋白酪氨酸磷酸酶 D2 轴对乳腺上皮细胞中的 ERBB2 信号传导至关重要

Mathangi Ramesh, Navasona Krishnan, Senthil K Muthuswamy, Nicholas K Tonks

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

使用变构抑制剂靶向 PTP1B 无序 C 端

Navasona Krishnan, Dorothy Koveal, Daniel H Miller, Bin Xue, Sai Dipikaa Akshinthala, Jaka Kragelj, Malene Ringkjøbing Jensen, Carla-Maria Gauss, Rebecca Page, Martin Blackledge, Senthil K Muthuswamy, Wolfgang Peti, Nicholas K Tonks

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1

硫氧还蛋白1对氧化型PTP1B和PTEN的再激活

Schwertassek, Ulla; Haque, Aftabul; Krishnan, Navasona; Greiner, Romy; Weingarten, Lars; Dick, Tobias P; Tonks, Nicholas K

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

抗炎化合物 BAY-11-7082 是蛋白酪氨酸磷酸酶的有效抑制剂

Navasona Krishnan, Gyula Bencze, Philip Cohen, Nicholas K Tonks

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

H2S诱导的磷酸酶PTP1B的硫氢化及其在内质网应激反应中的作用

Krishnan, Navasona; Fu, Cexiong; Pappin, Darryl J; Tonks, Nicholas K