日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

靶向治疗癌症中的p38α:挑战、机遇和新兴策略

Nebreda, Angel R

The PIN1-p38-CtIP signalling axis protects stalled replication forks from deleterious degradation

PIN1-p38-CtIP信号通路保护停滞的复制叉免受有害降解。

Vivalda, Francesca; Gatti, Marco; Manfredi, Letizia; Dogan, Hülya; Porro, Antonio; Collotta, Giulio; Ceppi, Ilaria; von Aesch, Christine; van Ackeren, Vanessa; Wild, Sebastian; Steger, Martin; Canovas, Begoña; Cubillos-Rojas, Monica; Riera, Antoni; Cejka, Petr; Nebreda, Angel R; Dibitetto, Diego; Rottenberg, Sven; Sartori, Alessandro A

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

调控应激激酶p38α的氧化还原依赖性构象开关的结构基础

Pous, Joan; Baginski, Blazej; Martin-Malpartida, Pau; González, Lorena; Scarpa, Margherita; Aragon, Eric; Ruiz, Lidia; Mees, Rebeca A; Iglesias-Fernández, Javier; Orozco, Modesto; Nebreda, Angel R; Macias, Maria J

Diversity and versatility of p38 kinase signalling in health and disease

p38激酶信号在健康和疾病中的多样性和多功能性

Canovas, Begoña; Nebreda, Angel R

Neuronal p38α mediates age-associated neural stem cell exhaustion and cognitive decline

神经元p38α介导与年龄相关的神经干细胞耗竭和认知衰退

Moreno-Cugnon, Leire; Revuelta, Miren; Arrizabalaga, Olatz; Colie, Sandra; Moreno-Valladares, Manuel; Jimenez-Blasco, Daniel; Gil-Bea, Francisco; Llarena, Irantzu; Bolaños, Juan Pedro; Nebreda, Angel R; Matheu, Ander

Failure to Inactivate Nuclear GSK3β by Ser(389)-Phosphorylation Leads to Focal Neuronal Death and Prolonged Fear Response

Ser(389)磷酸化导致核内GSK3β失活失败,进而引起局灶性神经元死亡和恐惧反应延长。

Thornton, Tina M; Hare, Brendan; Colié, Sandra; Pendlebury, William W; Nebreda, Angel R; Falls, William; Jaworski, Diane M; Rincon, Mercedes

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

通过增强型分子动力学模拟研究p38α MAP激酶在其经典激活和结合事件中自由能景观的变化

Kuzmanic, Antonija; Sutto, Ludovico; Saladino, Giorgio; Nebreda, Angel R; Gervasio, Francesco L; Orozco, Modesto

Targeting of non-oncogene addiction

针对非癌基因成瘾的靶向治疗

Igea, Ana; Gupta, Jalaj; Nebreda, Angel R

Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer

p38α丝裂原活化蛋白激酶在小鼠炎症性疾病和癌症模型中的作用

Gupta, Jalaj; Nebreda, Angel R

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation

p18Hamlet/SRCAP介导的组蛋白H2A.Z染色质整合在肌肉分化中起着至关重要的作用

Cuadrado, Ana; Corrado, Nadia; Perdiguero, Eusebio; Lafarga, Vanesa; Muñoz-Canoves, Pura; Nebreda, Angel R