日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion.

将表型组学与转录组学相结合,揭示了 22q11.2 缺失的细胞类型特异性形态和分子特征

Tegtmeyer Matthew, Liyanage Dhara, Han Yu, Hebert Kathryn B, Pei Ruifan, Way Gregory P, Ryder Pearl V, Hawes Derek, Tromans-Coia Callum, Cimini Beth A, Carpenter Anne E, Singh Shantanu, Nehme Ralda

βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia.

精神分裂症中βIV谱蛋白的丰度、细胞分布及对AKT/GSK3调控的敏感性

Di Re Jessica, Marini Michela, Hussain Syed Ibrar, Singh Aditya K, Venkatesh Akshaya, Alshammari Musaad A, Alshammari Tahani K, Hamoud Abdul-Rizaq Ali, Imami Ali Sajid, Haghighijoo Zahra, Fularcyzk Nickolas, Stertz Laura, Hawes Derek, Mosebarger Angela, Jernigan Jordan, Chaljub Claire, Nehme Ralda, Walss-Bass Consuelo, Schulmann Anton, Vawter Marquis P, McCullumsmith Robert, Damoiseaux Robert D, Limon Agenor, Labate Demetrio, Wells Michael F, Laezza Fernanda

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia

一个基础性的神经元蛋白网络模型,统一了精神分裂症中多模态的遗传、转录和蛋白质组扰动

Pintacuda, Greta; Hsu, Yu-Han H; Páleníková, Petra; Dubonyte, Ugne; Fornelos, Nadine; Chen, Miao; Mena, Daya; Biagini, Julia C; Botts, Travis; Martorana, Makayla; Rebelo, Danzel; Ching, Joshua K T; Crouse, Ethan; Gebre, Hilena; Adiconis, Xian; Haywood, Nathan; Simmons, Sean; Weïwer, Michel; Hawes, Derek; Pietilainen, Olli; Werge, Thomas; Li, Ka Wan; Smit, August B; Kirkeby, Agnete; Levin, Joshua Z; Nehme, Ralda; Lage, Kasper

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds

在“细胞村”中进行基因编辑,可以探索多种遗传背景下与疾病相关的突变。

Battaglia, Rachel A; Bolshakova, Sonia; Mazureac, Ilinca; Liyanage, Dhara; Pettinari, Noah; Johnson, Autumn; Crouse, Ethan; Habib, Sartaj; Flessas, Isabel; Nadig, Ajay; Hawes, Derek; Tegtmeyer, Matthew; Becker, Caroline; Ghosh, Sulagna; Genovese, Giulio; Hogan, Marina; Maglieri, Adrianna; Barrett, Lindy E; Daheron, Laurence; McCarroll, Steven A; Nehme, Ralda

CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology.

CellPHIE:将通路发现与扰动汇总分析相结合,揭示了亨廷顿病的通路,包括神经元发育和形态的遗传修饰因子

Kang Byunguk, Murphy Michael, Ng Christopher W, Leventhal Matthew Joseph, Huynh Nhan, Im Egun, Danquah Serwah, Housman David E, Nehme Ralda, Farhi Samouil L, Fraenkel Ernest

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.

星形胶质细胞提供的胆固醇驱动发育中神经元的突触基因表达程序和下游星形胶质细胞转录程序

Vartiainen Emilia, Liyanage Dhara, Mazureac Illinca, Battaglia Rachel A, Tegtmeyer Matthew, He Jax Xu, Räsänen Noora, Sealock Julia, McCarroll Steven, Nehme Ralda, Pietiläinen Olli

Human genetic variation shapes the response of neurons to interferons.

人类基因变异影响神经元对干扰素的反应

Andzelm Milena M, Bolshakova Sonia, Pettinari Noah, Tegtmeyer Matthew, Meyer Dan, Johnson Autumn, Mello Curtis J, Yu Connie T, Mazureac Ilinca, Genovese Giulio, Maglieri Adrianna, Ichihara Kiku, Hogan Marina, Hawes Derek, McCarroll Steven A, Nehme Ralda

Genomic, molecular, and cellular divergence of the human brain

人类大脑的基因组、分子和细胞分化

Nehme, Ralda; Pietiläinen, Olli; Barrett, Lindy E

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

小分子筛选揭示了调控干细胞来源星形胶质细胞中C4分泌的通路

Rapino, Francesca; Natoli, Ted; Limone, Francesco; O'Connor, Erin; Blank, Jack; Tegtmeyer, Matthew; Chen, William; Norabuena, Erika; Narula, Juhi; Hazelbaker, Dane; Angelini, Gabriella; Barrett, Lindy; O'Neil, Alison; Beattie, Ursula K; Thanos, Jessica M; de Rivera, Heather; Sheridan, Steven D; Perlis, Roy H; McCarroll, Steven A; Stevens, Beth; Subramanian, Aravind; Nehme, Ralda; Rubin, Lee L

Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits

同步CRISPR筛选和空间转录组学揭示细胞内、细胞间和功能性转录回路

Binan, Loϊc; Danquah, Serwah; Valakh, Vera; Simonton, Brooke; Bezney, Jon; Nehme, Ralda; Cleary, Brian; Farhi, Samouil L