日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The G-quadruplex experimental drug QN-302 impairs liposarcoma cell growth by inhibiting MDM2 expression and restoring p53 levels

G-四链体实验药物 QN-302 通过抑制 MDM2 表达和恢复 p53 水平来抑制脂肪肉瘤细胞生长

Beatrice Tosoni, Eisa Naghshineh, Irene Zanin, Irene Gallina, Lorenzo Di Pietro, Loredana Cleris, Matteo Nadai, Mara Lecchi, Paolo Verderio, Pietro Pratesi, Sandro Pasquali, Nadia Zaffaroni, Stephen Neidle, Marco Folini, Sara N Richter

Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene

N-甲基间卟啉IX与SLC2A1基因启动子中的左旋/右旋杂合G-四链体基序的相互作用

Seth, Paul; Xing, Eric; Hendrickson, Andrew D; Li, Kevin; Monsen, Robert; Chaires, Jonathan B; Neidle, Stephen; Yatsunyk, Liliya A

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells.

细胞适应性影响萘二酰亚胺 G-四链体配体在 ALT 阳性骨肉瘤细胞中的生物活性

Bidzinska Joanna, Di Pietro Lorenzo, Naghshineh Eisa, Pandini Cecilia, Doria Filippo, Zaffaroni Nadia, Gandellini Paolo, Neidle Stephen, Folini Marco

Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis

通过两种DNA嵌入剂靶向EGFR启动子中的GCCG位点抑制乳腺癌转移的结构和功能见解

Chih-Chun Chang,Hsin-Ju Li,Roshan Satange,Shan-Meng Lin,Tai-Lin Chen,Chi-Chien Lin,Stephen Neidle,Ming-Hon Hou

CsrA-mediated regulation of a virulence switch in Acinetobacter baumannii.

CsrA介导的鲍曼不动杆菌毒力转换调控

Singh Raja, Pérez-Varela María, Colquhoun Jennifer M, Kröger Carsten, Hamrock Fergal J, Shaibah Ali, Neidle Ellen L, Rather Philip N

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence

DNA序列特异性识别的替代方法:双阳离子二聚体的协同堆积——对化合物曲率、芳香结构和DNA序列的敏感性

Paul, Ananya; Terrell, J Ross; Farahat, Abdelbasset A; Ogbonna, Edwin N; Kumar, Arvind; Boykin, David W; Neidle, Stephen; Wilson, W David

Rewiring Aromatic Compound Consumption: Chromosomal Amplification and Evolution of a Foreign Pathway in Acinetobacter baylyi ADP1

芳香化合物消耗途径的重塑:鲍氏不动杆菌ADP1中外源途径的染色体扩增和进化

Alyssa C Baugh,Melissa P Tumen-Velasquez,Isabella R Zempel,Chantel V Duscent-Maitland,Lauren E Slarks,Justin B Defalco,Christopher W Johnson,Gregg T Beckham,Ellen L Neidle

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation

非CpG甲基化中水介导的顺式Watson-Crick/Hoogsteen碱基对形成的结构基础

Lin, Shan-Meng; Huang, Hsiang-Ti; Fang, Pei-Ju; Chang, Chi-Fon; Satange, Roshan; Chang, Chung-Ke; Chou, Shan-Ho; Neidle, Stephen; Hou, Ming-Hon

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs

利用表型方法发现高效G-四链体靶向药物

Neidle, Stephen

Regulation of tricarboxylate transport and metabolism in Acinetobacter baylyi ADP1

鲍氏不动杆菌ADP1中三羧酸转运和代谢的调控

Alyssa C Baugh,Justin B Defalco,Chantel V Duscent-Maitland,Melissa P Tumen-Velasquez,Nicole S Laniohan,Kayla Figatner,Timothy R Hoover,Anna C Karls,Kathryn T Elliott,Ellen L Neidle