日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene

N-甲基间卟啉IX与SLC2A1基因启动子中的左旋/右旋杂合G-四链体基序的相互作用

Seth, Paul; Xing, Eric; Hendrickson, Andrew D; Li, Kevin; Monsen, Robert; Chaires, Jonathan B; Neidle, Stephen; Yatsunyk, Liliya A

Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells.

细胞适应性影响萘二酰亚胺 G-四链体配体在 ALT 阳性骨肉瘤细胞中的生物活性

Bidzinska Joanna, Di Pietro Lorenzo, Naghshineh Eisa, Pandini Cecilia, Doria Filippo, Zaffaroni Nadia, Gandellini Paolo, Neidle Stephen, Folini Marco

Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence

DNA序列特异性识别的替代方法:双阳离子二聚体的协同堆积——对化合物曲率、芳香结构和DNA序列的敏感性

Paul, Ananya; Terrell, J Ross; Farahat, Abdelbasset A; Ogbonna, Edwin N; Kumar, Arvind; Boykin, David W; Neidle, Stephen; Wilson, W David

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation

非CpG甲基化中水介导的顺式Watson-Crick/Hoogsteen碱基对形成的结构基础

Lin, Shan-Meng; Huang, Hsiang-Ti; Fang, Pei-Ju; Chang, Chi-Fon; Satange, Roshan; Chang, Chung-Ke; Chou, Shan-Ho; Neidle, Stephen; Hou, Ming-Hon

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs

利用表型方法发现高效G-四链体靶向药物

Neidle, Stephen

Machine learning shows torsion angle preferences in left-handed and right-handed quadruplex DNAs

机器学习显示左旋和右旋四链体DNA的扭转角偏好

Li, Kevin; Yatsunyk, Liliya A; Neidle, Stephen

Water spines and networks in G-quadruplex structures

G-四链体结构中的水刺和水网络

Li, Kevin; Yatsunyk, Liliya; Neidle, Stephen

Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction

利用蒽基金属络合物靶向ALS/FTD相关的A-DNA扭结,可导致DNA骨架伸直和沟槽收缩。

Jhan, Cyong-Ru; Satange, Roshan; Wang, Shun-Ching; Zeng, Jing-Yi; Horng, Yih-Chern; Jin, Peng; Neidle, Stephen; Hou, Ming-Hon

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

结构水介导小分子与G-四链体核酸的结合

Neidle, Stephen

Beyond the double helix: DNA structural diversity and the PDB

超越双螺旋:DNA结构多样性与蛋白质数据库

Neidle, Stephen