日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough

小分子 eRF3a 降解剂通过促进提前终止密码子读通来挽救 CFTR 无义突变

Rhianna E Lee, Catherine A Lewis, Lihua He, Emily C Bulik-Sullivan, Samuel C Gallant, Teresa M Mascenik, Hong Dang, Deborah M Cholon, Martina Gentzsch, Lisa C Morton, John T Minges, Jonathan W Theile, Neil A Castle, Michael R Knowles, Adam J Kimple, Scott H Randell

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability

GI-530159 是一种新型、选择性、机械敏感的双孔结构域钾 (K2P ) 通道开放剂,可降低大鼠背根神经节神经元兴奋性

Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Mathie

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

亚型选择性小分子抑制剂揭示 Nav1.7 在伤害感受器电生成、轴突传导和突触前释放中的基本作用

Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

电压门控钠通道选择性小分子抑制剂的电压传感器相互作用位点

Ken McCormack, Sonia Santos, Mark L Chapman, Douglas S Krafte, Brian E Marron, Christopher W West, Michael J Krambis, Brett M Antonio, Shannon G Zellmer, David Printzenhoff, Karen M Padilla, Zhixin Lin, P Kay Wagoner, Nigel A Swain, Paul A Stupple, Marcel de Groot, Richard P Butt, Neil A Castle