日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

PALB2 和 53BP1 调控切除后同源重组 DNA 修复

Yifan Wang ,Yan Coulombe ,Wei-Ting Yueh ,Gregory D Conway ,Larissa Milano ,David J Glass ,Mélissa Thomas ,Amélie Rodrigue ,Joseph Nacson ,Dongbo Lu ,Andrea J Bernhardy ,Robert G Betsch ,Alyssa I Russo ,Gamal A Elfar ,Kathy Q Cai ,Joseph R Testa ,Mark Andrake ,Roland Dunbrack ,Gaorav P Gupta ,Bing Xia ,Eloise Dray ,Jean-Yves Masson ,Neil Johnson

RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors

RTx-303,一种口服生物利用度高的Polθ聚合酶抑制剂,可增强PARP抑制剂在BRCA突变肿瘤中的疗效

Gurushankar Chandramouly ,William Fried ,John Gordon ,Douglas Ralph ,Channita Keuk ,Sangeeta Kumari ,Mercy Ramanjulu ,William Auerbacher ,Leonid Minakhin ,Taylor Tredinnick ,Bernadette Tiberi ,George Morton ,Robert Betsch ,Kathy Q Cai ,Umeshkumar M Vekariya ,Mrityunjay Tyagi ,Tomasz Skorski ,Sergey Karakashev ,Neil Johnson ,Wayne E Childers Jr ,Xiaojiang S Chen ,Richard T Pomerantz

The effect of very preterm birth on the Five-Factor Model of personality traits: A meta-analysis of individual participant data

极早产对人格特质五因素模型的影响:一项基于个体参与者数据的荟萃分析

Liu, Yiwen; Realo, Anu; Mendonça, Marina; Baumann, Nicole; Bartmann, Peter; Räikkönen, Katri; Heinonen, Kati; Robinson, Rachel; Marlow, Neil; Johnson, Samantha; Ni, Yanyan; Kajantie, Eero; Hovi, Petteri; Tikanmäki, Marjaana; Wolke, Dieter

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM

冷冻电镜揭示Polθ解旋酶小分子抑制剂的结构基础

Fumiaki Ito # ,Ziyuan Li # ,Leonid Minakhin ,Gurushankar Chandramouly ,Mrityunjay Tyagi ,Robert Betsch ,John J Krais ,Bernadette Taberi ,Umeshkumar Vekariya ,Marissa Calbert ,Tomasz Skorski ,Neil Johnson ,Xiaojiang S Chen ,Richard T Pomerantz

FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs

FAM122A通过螺旋基序抑制B55α/PP2A,从而确保细胞周期间期进程和检查点控制。

Jason S Wasserman,Bulat Faezov,Kishan R Patel,Alison M Kurimchak,Seren M Palacio,David J Glass,Holly Fowle,Brennan C McEwan,Qifang Xu,Ziran Zhao,Lauren Cressey,Neil Johnson,James S Duncan,Arminja N Kettenbach,Roland L Dunbrack Jr,Xavier Graña

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

发现一种小分子抑制剂,该抑制剂能将Polθ捕获在DNA上,并与PARP抑制剂产生协同作用。

William Fried # ,Mrityunjay Tyagi # ,Leonid Minakhin ,Gurushankar Chandramouly ,Taylor Tredinnick ,Mercy Ramanjulu ,William Auerbacher ,Marissa Calbert ,Timur Rusanov ,Trung Hoang ,Nikita Borisonnik ,Robert Betsch ,John J Krais ,Yifan Wang ,Umeshkumar M Vekariya ,John Gordon ,George Morton ,Tatiana Kent ,Tomasz Skorski ,Neil Johnson ,Wayne Childers ,Xiaojiang S Chen ,Richard T Pomerantz

4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress

4'-乙炔基-2'-脱氧胞苷 (EdC) 通过诱导复制应激优先靶向淋巴瘤和白血病亚型。

Marissa L Calbert,Gurushankar Chandramouly,Clare M Adams,Magali Saez-Ayala,Tatiana Kent,Mrityunjay Tyagi,V S S Abhinav Ayyadevara,Yifan Wang,John J Krais,John Gordon,Jessica Atkins,Monika M Toma,Stéphane Betzi,Andrew S Boghossian,Matthew G Rees,Melissa M Ronan,Jennifer A Roth,Aaron R Goldman,Nicole Gorman,Ramkrishna Mitra,Wayne E Childers,Xavier Graña,Tomasz Skorski,Neil Johnson,Christian Hurtz,Xavier Morelli,Christine M Eischen,Richard T Pomerantz

Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities

Brca1 功能的遗传分离揭示了突变依赖的 Polθ 脆弱性

John J Krais, David J Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G Betsch, Andrea J Bernhardy, Alice M Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T Pomerantz, Gaorav P Gupta, Joseph R Testa, Neil Johnson

ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study

成年早产儿注意力缺陷多动障碍症状及诊断:系统评价、个体患者数据荟萃分析和登记数据链接研究

Robinson, Rachel; Girchenko, Polina; Pulakka, Anna; Heinonen, Kati; Lähdepuro, Anna; Lahti-Pulkkinen, Marius; Hovi, Petteri; Tikanmäki, Marjaana; Bartmann, Peter; Lano, Aulikki; Doyle, Lex W; Anderson, Peter J; Cheong, Jeanie L Y; Darlow, Brian A; Woodward, Lianne J; Horwood, L John; Indredavik, Marit S; Evensen, Kari Anne I; Marlow, Neil; Johnson, Samantha; de Mendonca, Marina Goulart; Kajantie, Eero; Wolke, Dieter; Räikkönen, Katri

Beneficial Effects of Preoperative Exercise on the Outcomes of Lumbar Fusion Spinal Surgery

术前锻炼对腰椎融合术疗效的有益影响

Lawrence, Denise C; Montazeripouragha, Amanallah; Wai, Eugene K; Roffey, Darren M; Phan, Kim M; Phan, Philippe; Stratton, Alexandra; Kingwell, Stephen; McIntosh, Greg; Soroceanu, Alex; Abraham, Edward; Bailey, Christopher S; Christie, Sean; Paquet, Jerome; Glennie, Andrew; Nataraj, Andrew; Hall, Hamilton; Fisher, Charles; Rampersaud, Y Raja; Thomas, Kenneth; Manson, Neil; Johnson, Michael; Zarrabian, Mohammad