日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

针对 PREX2/RAC1/PI3Kβ 信号轴可提高黑色素瘤临床相关治疗方法的敏感性

Catriona A Ford, Dana Koludrovic, Patricia P Centeno, Mona Foth, Elpida Tsonou, Nikola Vlahov, Nathalie Sphyris, Kathryn Gilroy, Courtney Bull, Colin Nixon, Bryan Serrels, Alison F Munro, John C Dawson, Neil O Carragher, Valeria Pavet, David C Hornigold, Philip D Dunne, Julian Downward, Heidi C E We

Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation

单细胞形态追踪细胞状态以识别肝脏分化的小分子调节剂

Rebecca E Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C Hay, Stuart J Forbes, Victoria L Gadd, Neil O Carragher

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

FAK通过调节糖酵解和谷氨酰胺氧化来调控胶质母细胞瘤干细胞的能量代谢。

Roza H A Masalmeh ,John C Dawson ,Virginia Alvarez Garcia ,Morwenna T Muir ,Roderick N Carter ,Giles E Hardingham ,Cameron Davies ,Rosina Graham ,Alex von Kriegsheim ,Jair Marques ,Chinmayi Pednekar ,Steven M Pollard ,Neil O Carragher ,Valerie G Brunton ,Margaret C Frame

Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma

评估 YAP-TEAD 抑制剂的研发管线表明,TEAD 抑制可抑制 NF2 突变型间皮瘤

Richard Cunningham ,Siyang Jia ,Krishna Purohit ,Michaela Noskova Fairley ,Marcin K Maniak ,Yue Lin ,Ning Sze Hui ,Rebecca E Graham ,Adriano G Rossi ,Justyna Cholewa-Waclaw ,Pierre O Bagnaninchi ,Neil O Carragher ,Carsten Gram Hansen

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

在人呼吸道基底细胞中进行的化合物筛选发现,Wnt通路激活剂具有潜在的促再生治疗作用。

Yuki Ishii ,Jessica C Orr ,Marie-Belle El Mdawar ,Denise R Bairros de Pilger ,David R Pearce ,Kyren A Lazarus ,Rebecca E Graham ,Marko Z Nikolić ,Robin Ketteler ,Neil O Carragher ,Sam M Janes ,Robert E Hynds

Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

胆汁酸类似物 INT-767 可减弱 MASLD 中 HSC 产生的异常基底膜

Prakash Ramachandran, Madara Brice, Elena F Sutherland, Anna M Hoy, Eleni Papachristoforou, Li Jia, Frances Turner, Timothy J Kendall, John A Marwick, Neil O Carragher, Denise Oro, Michael Feigh, Diana J Leeming, Mette J Nielsen, Morten A Karsdal, Nadine Hartmann, Mary Erickson, Luciano Adorini, Jon

Morphological profiling in human neural progenitor cells classifies hits in a pilot drug screen for Alzheimer's disease

人类神经祖细胞的形态学分析对阿尔茨海默病试验药物筛选中的药物进行分类

Amina H McDiarmid, Katerina O Gospodinova, Richard J R Elliott, John C Dawson, Rebecca E Graham, Marie-Therese El-Daher, Susan M Anderson, Sophie C Glen, Simon Glerup, Neil O Carragher, Kathryn L Evans

Discovery of senolytics using machine learning

利用机器学习发现抗衰老药物

Vanessa Smer-Barreto #, Andrea Quintanilla #, Richard J R Elliott, John C Dawson, Jiugeng Sun, Víctor M Campa, Álvaro Lorente-Macías, Asier Unciti-Broceta, Neil O Carragher, Juan Carlos Acosta, Diego A Oyarzún

Macrophages promote anti-androgen resistance in prostate cancer bone disease

巨噬细胞促进前列腺癌骨病中的抗雄激素抵抗

Xue-Feng Li # ,Cigdem Selli # ,Han-Lin Zhou ,Jian Cao ,Shuiqing Wu ,Ruo-Yu Ma ,Ye Lu ,Cheng-Bin Zhang ,Bijie Xun ,Alyson D Lam ,Xiao-Cong Pang ,Anu Fernando ,Zeda Zhang ,Asier Unciti-Broceta ,Neil O Carragher ,Prakash Ramachandran ,Neil C Henderson ,Ling-Ling Sun ,Hai-Yan Hu ,Gui-Bo Li ,Charles Sawyers ,Bin-Zhi Qian

Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice

斑马鱼幼虫药物筛选揭示小鼠脊髓损伤后继发性损伤的炎症相关调节剂

Ana-Maria Oprişoreanu, Fari Ryan, Claire Richmond, Yuliya Dzekhtsiarova, Neil O Carragher, Thomas Becker, Samuel David, Catherina G Becker