日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

斑马鱼内耳的单细胞转录组分析揭示了分子上不同的毛细胞和支持细胞亚型

Tuo Shi #, Marielle O Beaulieu #, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration

小鼠耳蜗 DNA 甲基化促进支持细胞成熟,导致毛细胞再生失败

John D Nguyen, Juan Llamas, Tuo Shi, J Gage Crump, Andrew K Groves, Neil Segil

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

ATOH1、GFI1 和 POU4F3 介导的细胞重编程表明,表观遗传变化和细胞间信号传导是成熟哺乳动物毛细胞再生的障碍。

Amrita A Iyer ,Ishwar Hosamani ,John D Nguyen ,Tiantian Cai ,Sunita Singh ,Melissa M McGovern ,Lisa Beyer ,Hongyuan Zhang ,Hsin-I Jen ,Rizwan Yousaf ,Onur Birol ,Jenny J Sun ,Russell S Ray ,Yehoash Raphael ,Neil Segil ,Andrew K Groves

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

GFI1 通过充当 ATOH1 的非 DNA 转录辅激活剂和 DNA 结合阻遏物来调节毛细胞分化

Hsin-I Jen, Sunita Singh, Litao Tao, Helen R Maunsell, Neil Segil, Andrew K Groves

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

小分子抑制剂Lats激酶可能促进哺乳动物有丝分裂后组织中Yap依赖性增殖

Nathaniel Kastan # ,Ksenia Gnedeva # ,Theresa Alisch ,Aleksandra A Petelski ,David J Huggins ,Jeanne Chiaravalli ,Alla Aharanov ,Avraham Shakked ,Eldad Tzahor ,Aaron Nagiel ,Neil Segil ,A J Hudspeth

Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration

增强子退役对感觉毛细胞再生造成表观遗传障碍

Litao Tao, Haoze V Yu, Juan Llamas, Talon Trecek, Xizi Wang, Zlatka Stojanova, Andrew K Groves, Neil Segil

Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

Foxc1 建立增强子对颅面软骨分化的可及性

Pengfei Xu #, Haoze V Yu #, Kuo-Chang Tseng, Mackenzie Flath, Peter Fabian, Neil Segil, J Gage Crump

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

通过原代体细胞直接谱系转换生成内耳毛细胞

Louise Menendez, Talon Trecek, Suhasni Gopalakrishnan, Litao Tao, Alexander L Markowitz, Haoze V Yu, Xizi Wang, Juan Llamas, Chichou Huang, James Lee, Radha Kalluri, Justin Ichida, Neil Segil

Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal

柯蒂氏器的大小受 Yap/Tead 介导的祖细胞自我更新控制

Ksenia Gnedeva, Xizi Wang, Melissa M McGovern, Matthew Barton, Litao Tao, Talon Trecek, Tanner O Monroe, Juan Llamas, Welly Makmura, James F Martin, Andrew K Groves, Mark Warchol, Neil Segil

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

小鼠椭圆囊毛细胞再生的转录组和表观遗传调控及其由 Atoh1 增强

Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Hongyuan Zhang, Haoze V Yu, Juan Llamas, Chenghang Zong, James F Martin, Neil Segil, Andrew K Groves