日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation

优化脑穿透性SARM1正构抑制剂及其矛盾的亚抑制激活作用

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00189
Green, Samantha A; Smith, Russell T; Grandner, Jessica M; Zeng, Mingshuo; Del Bel, Matthew; Zhu, Bing-Yan; Liang, Jun; Braun, Marie-Gabrielle; Sudhamsu, Jawahar; Wallweber, Heidi Ackerly; Boenig, Gladys; Murray, Jeremy; Shen, Xiaoli; Zhang, Renwei; Lai, Kwong Wah; Delwig, Anton; Breboneria, Maria Andrea; Ly, Justin; Ganti, Anjani; Nespi, Marika; Weber, Martin; Leahey, Rebecca; Hinz, Flora I; Chan, Bryan K
神经科学
发表日期：2025
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Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial

构象特异性KIT抑制剂联合治疗难治性胃肠道间质瘤患者的临床获益：一项1b/2a期非随机临床试验

期刊:Jama Oncology
影响因子:20.1
doi:10.1001/jamaoncol.2021.2086
Wagner, Andrew J; Severson, Paul L; Shields, Anthony F; Patnaik, Amita; Chugh, Rashmi; Tinoco, Gabriel; Wu, Guoxian; Nespi, Marika; Lin, Jack; Zhang, Ying; Ewing, Todd; Habets, Gaston; Burton, Elizabeth A; Matusow, Bernice; Tsai, James; Tsang, Garson; Shellooe, Rafe; Carias, Heidi; Chan, Katrina; Rezaei, Hamid; Sanftner, Laura; Marimuthu, Adhirai; Spevak, Wayne; Ibrahim, Prabha N; Inokuchi, Kerry; Alcantar, Oscar; Michelson, Glenn; Tsiatis, Athanasios C; Zhang, Chao; Bollag, Gideon; Trent, Jonathan C; Tap, William D
KIT
发表日期：2021
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Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling

通过靶向 Abl1/2 介导的 MEK/ERK/MYC 信号再激活来对抗黑色素瘤对 MAPK 抑制剂的获得性耐药性

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-020-19075-3
Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner
信号转导
肿瘤
黑色素瘤
MAPK/ERK
发表日期：2020
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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

在阿尔茨海默病模型中，使用 CSF1R 抑制剂持续清除小胶质细胞会损害实质斑块的形成。

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-019-11674-z
Elizabeth Spangenberg ，Paul L Severson ，Lindsay A Hohsfield ，Joshua Crapser ，Jiazhong Zhang ，Elizabeth A Burton ，Ying Zhang ，Wayne Spevak ，Jack Lin ，Nicole Y Phan ，Gaston Habets ，Andrey Rymar ，Garson Tsang ，Jason Walters ，Marika Nespi ，Parmveer Singh ，Stephanie Broome ，Prabha Ibrahim ，Chao Zhang ，Gideon Bollag ，Brian L West ，Kim N Green
胶质细胞
CSF1
CSF1R
细胞生物学
阿尔茨海默症
发表日期：2019
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RAF inhibitors that evade paradoxical MAPK pathway activation

逃避矛盾的 MAPK 通路激活的 RAF 抑制剂

期刊:Nature
影响因子:50.5
doi:10.1038/nature14982
Chao Zhang, Wayne Spevak, Ying Zhang, Elizabeth A Burton, Yan Ma, Gaston Habets, Jiazhong Zhang, Jack Lin, Todd Ewing, Bernice Matusow, Garson Tsang, Adhirai Marimuthu, Hanna Cho, Guoxian Wu, Weiru Wang, Daniel Fong, Hoa Nguyen, Songyuan Shi, Patrick Womack, Marika Nespi, Rafe Shellooe, Heidi Carias
信号转导
MAPK/ERK
发表日期：2015
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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

高特异性双重FMS和KIT激酶抑制剂的设计和药理学研究

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1219457110
Zhang, Chao; Ibrahim, Prabha N; Zhang, Jiazhong; Burton, Elizabeth A; Habets, Gaston; Zhang, Ying; Powell, Ben; West, Brian L; Matusow, Bernice; Tsang, Garson; Shellooe, Rafe; Carias, Heidi; Nguyen, Hoa; Marimuthu, Adhirai; Zhang, Kam Y J; Oh, Angela; Bremer, Ryan; Hurt, Clarence R; Artis, Dean R; Wu, Guoxian; Nespi, Marika; Spevak, Wayne; Lin, Paul; Nolop, Keith; Hirth, Peter; Tesch, Greg H; Bollag, Gideon
信号转导
KIT
多发性硬化症
发表日期：2013
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