日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model

肥胖和MASH对肝细胞区域性他汀类药物暴露的影响:基于渗透性受限多室肝脏模型的药效学见解

Murphy, William A; Sjöstedt, Noora; Mendes, Mailys De Sousa; Hartauer, Mattie; Brouwer, Kim L R; Neuhoff, Sibylle

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

在生理药代动力学框架下评估胆固醇代谢产物4β-羟基胆固醇作为肝脏CYP3A活性敏感内源性生物标志物的应用

Karkhanis, Aneesh V; Harwood, Matthew D; Stader, Felix; Bois, Frederic Y; Neuhoff, Sibylle

Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework

肝脏 OATP1B 区域分布:基于 PBPK 框架探讨利福平介导的药物相互作用的影响

Hartauer, Mattie; Murphy, William A; Brouwer, Kim L R; Southall, Roz; Neuhoff, Sibylle

A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator

Simcyp模拟器中基于生理的药代动力学建模的人群文件开发指南

Curry, Liam; Alrubia, Sarah; Bois, Frederic Y; Clayton, Ruth; El-Khateeb, Eman; Johnson, Trevor N; Faisal, Muhammad; Neuhoff, Sibylle; Wragg, Kris; Rostami-Hodjegan, Amin

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

基于生理学的肝病建模考量:从非酒精性脂肪肝(NAFL)到非酒精性脂肪性肝炎(NASH)

Murphy, William A; Adiwidjaja, Jeffry; Sjöstedt, Noora; Yang, Kyunghee; Beaudoin, James J; Spires, Jessica; Siler, Scott Q; Neuhoff, Sibylle; Brouwer, Kim L R

Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome

Madin-Darby犬肾细胞蛋白质组的实验室间变异性

Harwood, Matthew D; Zettl, Katharina; Weinheimer, Manuel; Pilla-Reddy, Venkatesh; Shen, Hong; Jacobs, Frank; Chu, Xiaoyan; Huth, Felix; Nakakariya, Masanori; Chothe, Paresh P; Neuhoff, Sibylle; Wiśniewski, Jacek R

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

药物转运蛋白的调控——从机制到临床影响:国际转运蛋白联盟白皮书

Brouwer, Kim L R; Evers, Raymond; Hayden, Elizabeth; Hu, Shuiying; Li, Cindy Yanfei; Meyer Zu Schwabedissen, Henriette E; Neuhoff, Sibylle; Oswald, Stefan; Piquette-Miller, Micheline; Saran, Chitra; Sjöstedt, Noora; Sprowl, Jason A; Stahl, Simone H; Yue, Wei

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

关键保护屏障中的转运蛋白调控:聚焦大脑和胎盘

Taggi, Valerio; Riera Romo, Mario; Piquette-Miller, Micheline; Meyer Zu Schwabedissen, Henriette E; Neuhoff, Sibylle

Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective

药物对肝肾 P-gp/BCRP 抑制的临床意义:国际转运体联盟的视角

Taskar, Kunal S; Yang, Xinning; Neuhoff, Sibylle; Patel, Mitesh; Yoshida, Kenta; Paine, Mary F; Brouwer, Kim L R; Chu, Xiaoyan; Sugiyama, Yuichi; Cook, Jack; Polli, Joseph W; Hanna, Imad; Lai, Yurong; Zamek-Gliszczynski, Maciej

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

Simcyp模拟器v21中CYP2C19酶丰度多态性设置的性能验证

Sychterz, Caroline; Gardner, Iain; Chiang, Manting; Rachumallu, Ramakrishna; Neuhoff, Sibylle; Perera, Vidya; Merali, Samira; Schmidt, Brian J; Gaohua, Lu