Neus Agell相关文献与解析，生知库 | 链接生命科学的每一步

Neus P Lorite #, Sonia Apostolova #, Marta Guasch-Vallés, Aaron Pryer, Fernando Unzueta, Raimundo Freire, Roger Solé-Soler, Neus Pedraza, Xavier Dolcet, Eloi Garí, Neus Agell, Elaine M Taylor, Neus Colomina, Jordi Torres-Rosell

信号转导

FCM

IHC-P

CHK1

发表日期：2024

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α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death

KRAS表面的α4-α5螺旋可以容纳一些小分子化合物，这些化合物能够增强KRAS信号传导并诱导CRC细胞死亡。

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms24010748

Baraa Abuasaker，Eduardo Garrido，Marta Vilaplana，Jesús Daniel Gómez-Zepeda，Sonia Brun，Marta Garcia-Cajide，Caroline Mauvezin，Montserrat Jaumot，Maria Dolors Pujol，Jaime Rubio-Martínez，Neus Agell

Peptidomimetics designed to bind to RAS effector domain are promising cancer therapeutic compounds

设计用于结合 RAS 效应结构域的肽模拟物是有前途的癌症治疗化合物

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-022-19703-6

Chiara Pallara #, Debora Cabot #, Josep Rivas #, Sonia Brun, Jesús Seco, Baraa Abuasaker, Teresa Tarragó, Montserrat Jaumot, Roger Prades, Neus Agell

肿瘤

发表日期：2022

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RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

RAD51 是一个可用药靶点，可在 DNA 复制压力下维持复制叉进展

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0266645

Sonia Feu, Fernando Unzueta, Amaia Ercilla, Alejandro Pérez-Venteo, Montserrat Jaumot, Neus Agell

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

核苷酸耗竭表明核糖体生物合成检查点受损，是防止 DNA 损伤的屏障

期刊:EMBO Journal

影响因子:9.4

doi:10.15252/embj.2019103838

Joffrey Pelletier #, Ferran Riaño-Canalias #, Eugènia Almacellas, Caroline Mauvezin, Sara Samino, Sonia Feu, Sandra Menoyo, Ana Domostegui, Marta Garcia-Cajide, Ramon Salazar, Constanza Cortés, Ricard Marcos, Albert Tauler, Oscar Yanes, Neus Agell, Sara C Kozma, Antonio Gentilella, George Thomas

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发表日期：2020

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Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse

急性羟基脲诱导的复制阻断导致复制体成分与新生 DNA 脱离，但不会引起复制叉崩溃

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-019-03206-1

Amaia Ercilla, Sonia Feu, Sergi Aranda, Alba Llopis, Sólveig Hlín Brynjólfsdóttir, Claus Storgaard Sørensen, Luis Ignacio Toledo, Neus Agell

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发表日期：2020

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Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness

近四倍体癌细胞表现出由复制压力引发的染色体不稳定性，并表现出增强的侵袭性

期刊:FASEB Journal

影响因子:4.4

doi:10.1096/fj.201700247RR

Darawalee Wangsa, Isabel Quintanilla, Keyvan Torabi, Maria Vila-Casadesús, Amaia Ercilla, Gregory Klus, Zeynep Yuce, Claudia Galofré, Miriam Cuatrecasas, Juan José Lozano, Neus Agell, Daniela Cimini, Antoni Castells, Thomas Ried, Jordi Camps

SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage

SUMO 调节 p21Cip1 的细胞内分布，并与 p21Cip1 一起促进 DNA 损伤后核仁中多蛋白复合物的形成

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0178925

Sonia Brun, Neus Abella, Maria T Berciano, Olga Tapia, Montserrat Jaumot, Raimundo Freire, Miguel Lafarga, Neus Agell

New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress

严重复制压力后，S 期 APC/CCdh1 激活可抑制新起源激发

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkw132

Amaia Ercilla, Alba Llopis, Sonia Feu, Sergi Aranda, Patrik Ernfors, Raimundo Freire, Neus Agell

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发表日期：2016

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Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress

p16INK4a 缺陷与端粒依赖性基因毒性应激之间的协同作用导致人类乳腺上皮细胞着丝粒畸变

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.4958

Daniel Domínguez, Purificación Feijoo, Aina Bernal, Amaia Ercilla, Neus Agell, Anna Genescà, Laura Tusell

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression

NSE1 环结构域在 Smc5/6 稳定性和 FANCM 独立分叉进展中的关键作用

α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death

KRAS表面的α4-α5螺旋可以容纳一些小分子化合物，这些化合物能够增强KRAS信号传导并诱导CRC细胞死亡。

Peptidomimetics designed to bind to RAS effector domain are promising cancer therapeutic compounds

设计用于结合 RAS 效应结构域的肽模拟物是有前途的癌症治疗化合物

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress

RAD51 是一个可用药靶点，可在 DNA 复制压力下维持复制叉进展

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

核苷酸耗竭表明核糖体生物合成检查点受损，是防止 DNA 损伤的屏障

Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse

急性羟基脲诱导的复制阻断导致复制体成分与新生 DNA 脱离，但不会引起复制叉崩溃

Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness

近四倍体癌细胞表现出由复制压力引发的染色体不稳定性，并表现出增强的侵袭性

SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage

SUMO 调节 p21Cip1 的细胞内分布，并与 p21Cip1 一起促进 DNA 损伤后核仁中多蛋白复合物的形成

New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress

严重复制压力后，S 期 APC/CCdh1 激活可抑制新起源激发

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress

p16INK4a 缺陷与端粒依赖性基因毒性应激之间的协同作用导致人类乳腺上皮细胞着丝粒畸变