日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Central control of dynamic gene circuits governs T cell rest and activation

动态基因回路的中央调控控制着T细胞的静息和激活。

Maya M Arce ,Jennifer M Umhoefer ,Nadia Arang ,Sivakanthan Kasinathan ,Jacob W Freimer ,Zachary Steinhart ,Haolin Shen ,Minh T N Pham ,Mineto Ota ,Anika Wadhera ,Rama Dajani ,Dmytro Dorovskyi ,Yan Yi Chen ,Qi Liu ,Yuan Zhou ,Danielle L Swaney ,Kirsten Obernier ,Brian R Shy ,Julia Carnevale ,Ansuman T Satpathy ,Nevan J Krogan ,Jonathan K Pritchard ,Alexander Marson

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

生物分子凝聚体中RNA的选择性隔离决定细胞命运的转变

Pessina, Patrizia; Nevo, Mika; Shi, Junchao; Kodali, Srikanth; Casas, Eduard; Cui, Yingzhi; Richards, Alicia L; Park, Emily J; Chen, Xi; Levin-Ferreyra, Florencia; Rivera Tostado, Alejandra; Stevenson, Erica; Krogan, Nevan J; Swaney, Danielle L; Ying, Qilong; Chen, Qi; Brumbaugh, Justin; Di Stefano, Bruno

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

HBV通过重塑PP2A复合物来重新连接肝细胞癌中的激酶信号通路

Turnham Rigney E, Pitea Adriana, Jang Gwendolyn M, Xu Zhong, Lim Huat Chye, Choi Alex L, Von Dollen John, Levin Rebecca S, Webber James T, McCarthy Elizabeth, Hu Junjie, Li Xiaolei, Che Li, Singh Ananya, Yoon Alex, Chan Gary K L, Kelley Robin K, Swaney Danielle L, Zhang Wei, Bandyopadhyay Sourav, Theis Fabian J, Eckhardt Manon, Chen Xin, Shokat Kevan M, Ideker Trey, Krogan Nevan J, Gordan John D

Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.

溶酶体蛋白质组学揭示了神经元 APOE4 相关溶酶体功能障碍的机制。

Krogsaeter Einar K, McKetney Justin, Valiente-Banuet Leopoldo, Marquez Angelica, Willis Alexandra, Cakir Zeynep, Stevenson Erica, Jang Gwendolyn M, Rao Antara, Li Emmy, Zhou Anton, Attili Anjani, Chang Timothy S, Kampmann Martin, Huang Yadong, Krogan Nevan J, Swaney Danielle L

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.

转录组学、蛋白质组学和功能遗传图谱剖析了神经纤维蛋白在周围神经系统中的功能

Vasudevan Harish N, Arang Nadia, Sacconi Nunez Maria, Kennedy Patrick, Payne Emily, Mohabeer Sarah, Chien Julian, Wright Aaron, Sale Matthew J, Krogan Nevan J, Forget Antoine, McCormick Frank

Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.

对突触进行综合多组学表征,揭示了与神经发育障碍相关的 RNA 加工因子和泛素连接酶

Mei Yuan, Gosztyla Maya L, Tan Xinzhu, Dozier Lara E, Wilkinson Brent, McKetney Justin, Lee John, Chen Michael, Tsai Dorothy, Kopalle Hema, Gritsenko Marina A, Hartel Nicolas, Graham Nicholas A, Flores Ilse, Gilmore-Hall Stephen K, Xu Shuhao, Marquez Charlotte A, Liu Sophie N, Fong Dylan, Chen Jing, Licon Kate, Hong Derek, Wright Sarah N, Kreisberg Jason F, Nott Alexi, Smith Richard D, Qian Wei-Jun, Swaney Danielle L, Iakoucheva Lilia M, Krogan Nevan J, Patrick Gentry N, Zhou Yang, Feng Guoping, Coba Marcelo P, Yeo Gene W, Ideker Trey

An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

整合蛋白质组学方法鉴定出病毒和宿主蛋白上的磷酸化位点,这些位点调控西尼罗病毒感染。

Zachary Walter,Minghua Li,Melissa Molho,Lauren Berish,Andrew Isopi,Mary O'Mara,Mark Dittmar,Chike Nwaezeapu,Alicia Richards,Martin McCullagh,Nevan J Krogan,Sara Cherry,Jeffrey R Johnson,Holly Ramage

The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection

衣原体效应蛋白Dre1与动力蛋白结合,在感染过程中重新定位宿主细胞器。

Jessica Sherry,Komal Ishwar Pawar,Lee Dolat,Erin Smith,I-Chang Chang,Khavong Pha,Robyn Kaake,Danielle L Swaney,Clara Herrera,Eleanor McMahon,Robert J Bastidas,Jeffrey R Johnson,Raphael H Valdivia,Nevan J Krogan,Cherilyn A Elwell,Kliment Verba,Joanne N Engel