日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A curious concept of CNS clearance

中枢神经系统清除的奇特概念

Plá, Virginia; Kroesbergen, Erik; Deng, Saiyue; Giannetto, Michael J; Hablitz, Lauren M; Newbold, Evan; Ladrón-de-Guevara, Antonio; Esmail, Tina; Gomolka, Ryszard Stefan; Mori, Yuki; Goldman, Steven A; Kelley, Douglas H; Thomas, John H; Nedergaard, Maiken

Mechanical Ventilation Suppresses Glymphatic Function in Parallel with Delirium-Like Symptoms in Mice

机械通气抑制小鼠脑淋巴功能,并伴随谵妄样症状

Liu, Guojun; Wang, Jianbo; Tong, Tianyi; Arbanas, Lucille G; Liang, SiRu; Newbold, Evan; Kroesbergen, Erik; Boesen, Hans Christian; Nedergaard, Maiken; Du, Ting

In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells.

体内筛选和淋巴系统递送经基因工程改造靶向人类神经胶质祖细胞的 AAV5 衣壳

Cona Alexander, Newbold Evan, Kesmen Deniz, Snape Rajiv, Danner Jessica, White Nicholas, Borden William, Iseson Abigail, Schanz Steven J, Chandler-Militello Devin, Li Xiaojie, Cano Jose C, Mariani John N, Nedergaard Maiken, Benraiss Abdellatif, Goldman Steven A

Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.

短暂性高血糖(而非慢性高血糖)会加速眼部淋巴运输

Delle Christine, Wang Xiaowei, Giannetto Michael, Newbold Evan, Peng Weiguo, Gomolka Ryszard Stefan, Ladrón-de-Guevara Antonio, Cankar Neža, Schiøler Nielsen Elise, Kjaerby Celia, Weikop Pia, Mori Yuki, Nedergaard Maiken

Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271.

水通道蛋白-4抑制剂AER-271可抑制脑淋巴液运输

Giannetto Michael J, Gomolka Ryszard S, Gahn-Martinez Daniel, Newbold Evan J, Bork Peter A R, Chang Ethan, Gresser Michael, Thompson Trevor, Mori Yuki, Nedergaard Maiken

Blood osmolytes such as sugar can drive brain fluid flows in a poroelastic model

血液渗透压调节剂(例如糖)可以在多孔弹性模型中驱动脑液流动。

Bork, Peter A R; Gianetto, Michael; Newbold, Evan; Hablitz, Lauren; Bohr, Tomas; Nedergaard, Maiken

A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor

CX-8998治疗特发性震颤的II期概念验证性随机安慰剂对照试验

Papapetropoulos, Spyros; Lee, Margaret S; Versavel, Stacey; Newbold, Evan; Jinnah, Hyder A; Pahwa, Rajesh; Lyons, Kelly E; Elble, Rodger; Ondo, William; Zesiewicz, Theresa; Hedera, Peter; Handforth, Adrian; Elder, Jenna; Versavel, Mark

Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models

苏维卡胺(一种选择性T型钙通道调节剂)在临床前模型中逆转硼替佐米诱导的神经毒性

Meregalli, Cristina; Maricich, Yuri; Cavaletti, Guido; Canta, Annalisa; Carozzi, Valentina A; Chiorazzi, Alessia; Newbold, Evan; Marmiroli, Paola; Ceresa, Cecilia; Diani, Arthur; Papapetropoulos, Spyros; Lee, Margaret S

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of CX-8998, a Selective Modulator of the T-Type Calcium Channel in Inadequately Treated Moderate to Severe Essential Tremor: T-CALM Study Design and Methodology for Efficacy Endpoint and Digital Biomarker Selection

一项针对中重度原发性震颤(治疗不足)的 CX-8998(一种选择性 T 型钙通道调节剂)的 II 期随机、双盲、安慰剂对照试验:T-CALM 研究的疗效终点和数字生物标志物选择设计及方法

Papapetropoulos, Spyros; Lee, Margaret S; Boyer, Stacey; Newbold, Evan J