日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks.

SPRTN 的双重泛素结合模式确保了 DNA-蛋白质交联的快速时空蛋白水解

Song Wei, Zhao Yichen, Ruggiano Annamaria, Redfield Christina, Newman Joseph A, Zhu Xiaosheng, García-Flores Marta, Cruz-Migoni Abimael, Roddan Rebecca, Pérez-Ràfols Anna, McHugh Peter J, Elliott Paul R, Ramadan Kristijan

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts

胶体提供了一种通过可转移的纳米抗体突变来提高晶体可靠性和多样性的途径,这些突变引入了组成性的紧密接触。

Ye, Mingda; Makola, Mpho; Richards, Mark W; Newman, Joseph A; Fairhead, Michael; Burgess, Selena G; Wu, Zhihuang; Maclean, Elizabeth; Wright, Nathan D; Koekemoer, Lizbé; Thompson, Andrew; Bezerra, Gustavo Arruda; Yi, Gangshun; Li, Huanyu; Rangel, Victor L; Mamalis, Dimitrios; Aitkenhead, Hazel; Davis, Benjamin G; Gilbert, Robert J C; Duerr, Katharina L; Bayliss, Richard; Gileadi, Opher; von Delft, Frank

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

CACHE挑战#2:靶向SARS-CoV-2解旋酶Nsp13的RNA位点

Herasymenko, Oleksandra; Silva, Madhushika; Abu-Saleh, Abd Al-Aziz A; Ahmad, Ayaz; Alvarado-Huayhuaz, Jesus; Arce, Oscar E A; Armstrong, Roly J; Arrowsmith, Cheryl; Bachta, Kelly E; Beck, Hartmut; Berta, Denes; Bieniek, Mateusz K; Blay, Vincent; Bolotokova, Albina; Bourne, Philip E; Breznik, Marko; Brown, Peter J; Campbell, Aaron D G; Carosati, Emanuele; Chau, Irene; Cole, Daniel J; Cree, Ben; Dehaen, Wim; Denzinger, Katrin; Dos Santos Machado, Karina; Dunn, Ian; Durai, Prasannavenkatesh; Edfeldt, Kristina; Edwards, Aled; Fayne, Darren; Felfoldi, Daniel; Friston, Kallie; Ghiabi, Pegah; Gibson, Elisa; Günther, Judith; Gunnarsson, Anders; Hillisch, Alexander; Houston, Douglas R; Jensen, Jan Halborg; Harding, Rachel J; Harris, Kate S; Hoffer, Laurent; Hogner, Anders; Horton, Joshua T; Houliston, Scott; Hultquist, Judd F; Hutchinson, Ashley; Irwin, John J; Jukič, Marko; Kandwal, Shubhangi; Karlova, Andrea; Katis, Vittorio L; Kich, Ryan P; Kireev, Dmitri; Koes, David; Inniss, Nicole L; Lessel, Uta; Liu, Sijie; Loppnau, Peter; Lu, Wei; Martino, Sam; McGibbon, Miles; Meiler, Jens; Mettu, Akhila; Money-Kyrle, Sam; Moretti, Rocco; Moroz, Yurii S; Muvva, Charuvaka; Newman, Joseph A; Obendorf, Leon; Paige, Brooks; Pandit, Amit; Park, Keunwan; Perveen, Sumera; Pirie, Rachael; Poda, Gennady; Protopopov, Mykola; Pütter, Vera; Ricci, Federico; Roper, Natalie J; Rosta, Edina; Rzhetskaya, Margarita; Sabnis, Yogesh; Satchell, Karla J F; Schmitt Kremer, Frederico; Scott, Thomas; Seitova, Almagul; Steinmann, Casper; Talagayev, Valerij; Tarkhanova, Olga O; Tatum, Natalie J; Treleaven, Dakota; Velasque Werhli, Adriano; Walters, W Patrick; Wang, Xiaowen; Wells, Jude; Wells, Geoffrey; Westermaier, Yvonne; Wolber, Gerhard; Wortmann, Lars; Zhang, Jixian; Zhao, Zheng; Zheng, Shuangjia; Schapira, Matthieu

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease

CSB刺激SNM1A DNA修复核酸酶的分子基础

Roddan, Rebecca; Schaich, Matthew A; Nathan, William J; Kis, Iulia; Pierangelini, Andrea; Henderson, Lucy R; van Wee, Raman; Martin, Louise; El-Sagheer, Afaf; Kukura, Philipp; Brown, Tom; O'Brien, Darragh; Newman, Joseph A; Wilson, David M 3rd; Schofield, Christopher J; Van Houten, Bennett; McHugh, Peter J

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

具有细胞活性的小分子抑制剂证实了SNM1A DNA修复核酸酶作为癌症靶点的价值。

Bielinski, Marcin; Henderson, Lucy R; Yosaatmadja, Yuliana; Swift, Lonnie P; Baddock, Hannah T; Bowen, Matthew J; Brem, Jürgen; Jones, Philip S; McElroy, Stuart P; Morrison, Angus; Speake, Michael; van Boeckel, Stan; van Doornmalen, Els; van Groningen, Jan; van den Hurk, Helma; Gileadi, Opher; Newman, Joseph A; McHugh, Peter J; Schofield, Christopher J

Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing

从分子层面揭示了CSB在链间交联过程中对SNM1A核酸酶活性的刺激作用

Roddan, Rebecca; Nathan, William J; Newman, Joseph A; El-Sagheer, Afaf; Wilson, David M; Brown, Tom; Schofield, Christopher J; McHugh, Peter J

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

SARS-CoV-2 NSP14 的晶体结构和片段筛选揭示了核糖核酸外切酶激活和 mRNA 加帽的细节,并为抗病毒药物的开发提供了起点

Imprachim Nergis, Yosaatmadja Yuliana, Newman Joseph A

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

对 Artemis 核酸内切酶的结构和机制的深入研究及其抑制策略

Yosaatmadja, Yuliana; Baddock, Hannah T; Newman, Joseph A; Bielinski, Marcin; Gavard, Angeline E; Mukhopadhyay, Shubhashish M M; Dannerfjord, Adam A; Schofield, Christopher J; McHugh, Peter J; Gileadi, Opher

RecQ helicases in DNA repair and cancer targets

RecQ解旋酶在DNA修复和癌症靶点中的作用

Newman, Joseph A; Gileadi, Opher