A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone
通过对甲状腺激素抵抗的第三组突变进行表征,揭示了TRβ配体结合域螺旋3在辅激活因子募集中的作用
期刊:EMBO Journal
影响因子:8.3
doi:10.1093/emboj/17.16.4760
Collingwood, T N; Wagner, R; Matthews, C H; Clifton-Bligh, R J; Gurnell, M; Rajanayagam, O; Agostini, M; Fletterick, R J; Beck-Peccoz, P; Reinhardt, W; Binder, G; Ranke, M B; Hermus, A; Hesch, R D; Lazarus, J; Newrick, P; Parfitt, V; Raggatt, P; de Zegher, F; Chatterjee, V K