日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC.

灵敏的荧光生物传感器揭示了 PKC 的亚细胞差异性调控

Su Qi, Zhang Jing, Lin Wei, Zhang Jin-Fan, Newton Alexandra C, Mehta Sohum, Yang Jing, Zhang Jin

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

突变朊病毒蛋白增强NMDA受体活性,激活蛋白激酶C (PKC),并在小鼠中引发快速兴奋性毒性。

Lin, Joie; Callender, Julia A; Mayfield, Joshua E; McClatchy, Daniel B; Ojeda-Juárez, Daniel; Pourhamzeh, Mahsa; Soldau, Katrin; Kurt, Timothy D; Danque, Garrett A; Khuu, Helen; Ronson, Josephina E; Pizzo, Donald P; Du, Yixing; Gruber, Maxwell A; Sevillano, Alejandro M; Wang, Jin; Orrú, Christina D; Chen, Joy; Funk, Gail; Aguilar-Calvo, Patricia; Aulston, Brent D; Roy, Subhojit; Rho, Jong M; Bui, Jack D; Newton, Alexandra C; Lipton, Stuart A; Caughey, Byron; Patrick, Gentry N; Doré, Kim; Yates, John R 3rd; Sigurdson, Christina J

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.

PKCη错义突变增强了高尔基体定位的信号传导,并且与隐性遗传的家族性阿尔茨海默病有关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases

利用蛋白激酶C和Akt的C-spine突变作为构建稳定假激酶的一种新型通用方法

Hodapp, Stefanie J; Kao, Tiffany H; Wu, Jian; Balasuriya, Nileeka; Antal, Corina E; Taylor, Susan S; Newton, Alexandra C

Novel C1A Domain Variant in Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Decreases Autoinhibition

脊髓小脑性共济失调14型中蛋白激酶Cγ的新型C1A结构域变体降低了自身抑制

Raj Ghosh, Gayatri; Kao, Tiffany H; Steigerwald, Connolly G; Chan, Nora L; Newton, Alexandra C; Abreu, Nicolas J

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring

催化失活的蛋白激酶Cα突变通过通路重连驱动脊索样胶质瘤的发生

Bellamy, Charlotte; Tovell, Hannah; Schwaighofer, Selina; Baffi, Timothy R; Arslan, Janan; Letourneur, Quentin; Dingli, Florent; Loew, Damarys; Kornev, Alexandr; Lerond, Julie; Kao, Tiffany H; Liva, Stephane; Izac, Brigitte; Andrieu, Muriel; Adle-Biassette, Homa; Barnier, Jean-Vianney; Stefan, Eduard; Sanson, Marc; Newton, Alexandra C; Bielle, Franck

Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.

蛋白激酶 C eta 可增强高尔基体定位的信号传导,并以隐性遗传方式与阿尔茨海默病相关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Protein kinase C showcases allosteric control: activation of LRRK1

蛋白激酶C展现变构调控:LRRK1的激活

Tovell, Hannah; Newton, Alexandra C

Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration

一枚硬币的两面:蛋白质激酶Cγ在癌症和神经退行性疾病中的作用

Pilo, Caila A; Newton, Alexandra C

mTOR Regulation of AGC Kinases: New Twist to an Old Tail

mTOR调控AGC激酶:旧故事的新转折

Baffi, Timothy R; Newton, Alexandra C