日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability

POLγ Y951N 患者突变会破坏 DNA 合成和校正之间的转换，从而引发线粒体 DNA 不稳定。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2417477122
Forslund, Josefin M E; Nguyen, Tran V H; Parkash, Vimal; Berner, Andreas; Goffart, Steffi; Pohjoismäki, Jaakko L O; Wanrooij, Paulina H; Johansson, Erik; Wanrooij, Sjoerd
线粒体
发表日期：2025
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Activating AMPK improves pathological phenotypes due to mtDNA depletion.

激活 AMPK 可改善由 mtDNA 耗竭引起的病理表型

期刊:FEBS Journal
影响因子:4.2
doi:10.1111/febs.70006
Carvalho Gustavo, Nguyen Tran V H, Repolês Bruno, Forslund Josefin M E, Wijethunga W M Ruchitha Rukmal, Ranjbarian Farahnaz, Mendes Isabela C, Gorospe Choco Michael, Chaudhari Namrata, Falabella Micol, Doimo Mara, Wanrooij Sjoerd, Pitceathly Robert D S, Hofer Anders, Wanrooij Paulina H
信号转导
AMPK
发表日期：2025
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Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

线粒体G-四链体形成增强会阻碍复制叉的延伸，导致人类细胞中线粒体DNA的丢失。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkad535
Doimo, Mara; Chaudhari, Namrata; Abrahamsson, Sanna; L'Hôte, Valentin; Nguyen, Tran V H; Berner, Andreas; Ndi, Mama; Abrahamsson, Alva; Das, Rabindra Nath; Aasumets, Koit; Goffart, Steffi; Pohjoismäki, Jaakko L O; López, Marcela Dávila; Chorell, Erik; Wanrooij, Sjoerd
线粒体
细胞生物学
发表日期：2023
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