Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium
CLN3 基因突变导致青少年神经元蜡样脂褐素沉积症，该基因的缺失会导致视网膜色素上皮细胞代谢受损和自噬诱导
期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease
影响因子:4.2
doi:10.1016/j.bbadis.2020.165883
Yu Zhong, Kabhilan Mohan, Jinpeng Liu, Ahmad Al-Attar, Penghui Lin, Robert M Flight, Qiushi Sun, Marc O Warmoes, Rahul R Deshpande, Huijuan Liu, Kyung Sik Jung, Mihail I Mitov, Nianwei Lin, D Allan Butterfield, Shuyan Lu, Jinze Liu, Hunter N B Moseley, Teresa W M Fan, Mark E Kleinman, Qing Jun Wang
代谢
信号转导
神经
细胞生物学
上皮细胞
WB
Autophagy
