日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

APOE 基因调控小胶质细胞免疫代谢,以应对年龄、淀粉样蛋白病理和炎症反应。

Sangderk Lee ,Nicholas A Devanney ,Lesley R Golden ,Cathryn T Smith ,James L Schwartz ,Adeline E Walsh ,Harrison A Clarke ,Danielle S Goulding ,Elizabeth J Allenger ,Gabriella Morillo-Segovia ,Cassi M Friday ,Amy A Gorman ,Tara R Hawkinson ,Steven M MacLean ,Holden C Williams ,Ramon C Sun ,Josh M Morganti ,Lance A Johnson

APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes

APOE4 驱动星形胶质细胞的转录异质性和适应不良的免疫代谢反应

Sangderk Lee, Holden C Williams, Amy A Gorman, Nicholas A Devanney, Douglas A Harrison, Adeline E Walsh, Danielle S Goulding, Tony Tuck, James L Schwartz, Diana J Zajac, Shannon L Macauley, Steven Estus, Tcw Julia, Lance A Johnson, Josh M Morganti

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

APOΕ4 降低女性的能量消耗,并通过增加有氧糖酵解的通量来削弱葡萄糖氧化

Brandon C Farmer, Holden C Williams, Nicholas A Devanney, Margaret A Piron, Grant K Nation, David J Carter, Adeline E Walsh, Rebika Khanal, Lyndsay E A Young, Jude C Kluemper, Gabriela Hernandez, Elizabeth J Allenger, Rachel Mooney, Lesley R Golden, Cathryn T Smith, J Anthony Brandon, Vedant A Gupta