日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer

代谢建模与成像相结合用于结直肠癌治疗靶点的筛选

Niki Tavakoli # ,Emma J Fong # ,Abigail Coleman ,Yu-Kai Huang ,Mathias Bigger ,Michael E Doche ,Seungil Kim ,Heinz-Josef Lenz ,Nicholas A Graham ,Paul Macklin ,Stacey D Finley ,Shannon M Mumenthaler

A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

SHLP2 的自然变体是帕金森病的保护因素

Su-Jeong Kim, Brendan Miller, Nicolas G Hartel, Ricardo Ramirez 2nd, Regina Gonzalez Braniff, Naphada Leelaprachakul, Amy Huang, Yuzhu Wang, Thalida Em Arpawong, Eileen M Crimmins, Penglong Wang, Xianbang Sun, Chunyu Liu, Daniel Levy, Kelvin Yen, Giselle M Petzinger, Nicholas A Graham, Michael W Jak

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

突触后密度信号中枢 TNIK 的突变会破坏人类神经发育障碍模型中的 PSD 信号传导

Jianzhi Jiang, Brent Wilkinson, Ilse Flores, Nicolas Hartel, Simeon R Mihaylov, Veronica A Clementel, Helen R Flynn, Fowsan S Alkuraya, Sila Ultanir, Nicholas A Graham, Marcelo P Coba

Merging Metabolic Modeling and Imaging for Screening Therapeutic Targets in Colorectal Cancer

结合代谢模型和成像技术筛选结直肠癌治疗靶点

Niki Tavakoli, Emma J Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A Graham, Paul Macklin, Stacey D Finley, Shannon M Mumenthaler

Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing

药物机制富集分析提高了药物再利用治疗的优先性

Belinda B Garana, James H Joly, Alireza Delfarah, Hyunjun Hong, Nicholas A Graham

Glutamine-dependent signaling controls pluripotent stem cell fate

谷氨酰胺依赖性信号通路调控多能干细胞命运

Vivian Lu ,Irena J Roy ,Alejandro Torres Jr ,James H Joly ,Fasih M Ahsan ,Nicholas A Graham ,Michael A Teitell

The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology

CARM1 转录组和精氨酸甲基蛋白质组介导骨骼肌整合生物学

Tiffany L vanLieshout, Derek W Stouth, Nicolas G Hartel, Goutham Vasam, Sean Y Ng, Erin K Webb, Irena A Rebalka, Andrew I Mikhail, Nicholas A Graham, Keir J Menzies, Thomas J Hawke, Vladimir Ljubicic

Elucidating tumor-stromal metabolic crosstalk in colorectal cancer through integration of constraint-based models and LC-MS metabolomics

通过整合基于约束的模型和 LC-MS 代谢组学阐明结直肠癌中的肿瘤-基质代谢串扰

Junmin Wang, Alireza Delfarah, Patrick E Gelbach, Emma Fong, Paul Macklin, Shannon M Mumenthaler, Nicholas A Graham, Stacey D Finley

Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time

膀胱癌细胞迅速自发地转向可实时追踪的顺铂耐药氧化磷酸化

Tong Xu #, Jason A Junge #, Alireza Delfarah, Yi-Tsung Lu, Cosimo Arnesano, Maheen Iqbal, Kevin Delijani, Tien-Chan Hsieh, Emmanuelle Hodara, Hemal H Mehta, Pinchas Cohen, Nicholas A Graham, Scott E Fraser, Amir Goldkorn

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

MOTS-c 是一种由运动引起的线粒体编码调节剂,可调节与年龄相关的身体机能衰退和肌肉稳态

Joseph C Reynolds, Rochelle W Lai, Jonathan S T Woodhead, James H Joly, Cameron J Mitchell, David Cameron-Smith, Ryan Lu, Pinchas Cohen, Nicholas A Graham, Bérénice A Benayoun, Troy L Merry, Changhan Lee