Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性
期刊:Cancer Discovery
影响因子:29.7
doi:10.1158/2159-8290.CD-23-0704
Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi
