日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiple myeloma risk linked to DNA damage response genes

多发性骨髓瘤风险与DNA损伤反应基因相关

Conry, Michael; Ostrovnaya, Irina; Kemel, Yelena; Sinha, Saloni; Baughn, Linda B; Avery, Brian; Maclachlan, Kylee; Groner, Victoria; Banaszak, Lauren; Norman, Aaron; Boddicker, Nicholas J; Clay-Gilmour, Alyssa; Kumar, Shaji; Kim, Ellen; Dandiker, Sita; Waghmare, Mitul; Slager, Susan; Sborov, Douglas W; Garber, Judy; Brown, Elizabeth E; Hildebrandt, Michelle; Hari, Parameshwaran; Camp, Nicola; Vachon, Celine; Usmani, Saad; Offit, Kenneth; Joseph, Vijai

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.

以表位为导向发现能有效中和 Omicron 变体的 SARS-CoV-2 抗体。

Zost Seth J, Suryadevara Naveenchandra, Williamson Lauren E, Scheaffer Suzanne M, Binshtein Elad, Buchman Cameron D, Johnson Nicole V, Catanzaro Nicholas J, Ravera Silvia, Chapman Nathaniel S, Myers Luke, Ramamohan Ajit R, Handal Laura S, Nguyen Doan C, Trivette Andrew, Martinez James R, Villalobos Eduardo, Rutherford Stacey A, Eun-Hyung Lee F, Schäfer Alexandra, Baric Ralph S, McLellan Jason S, Diamond Michael S, Carnahan Robert H, Crowe James E Jr

The genomic impact of population connectivity and decline in Africa's elephants

非洲象种群连通性和数量下降的基因组影响

Pečnerová, Patrícia; Ishida, Yasuko; Garcia-Erill, Genís; Bertola, Laura D; Santander, Cindy G; Liu, Xiaodong; Brüniche-Olsen, Anna; Khan, Anubhab; Hennelly, Lauren M; Balboa, Renzo F; Lin, Long; Rasmussen, Malthe S; Wang, Xi; Schubert, Mikkel; Al-Chaer, Amal; Urbaniak, Sylwia; Nobuta, Kan; Treadup, Sasha; Viaud-Martinez, Karine A; de Flamingh, Alida; Malhi, Ripan S; Bird, Savanah; Ting, Nelson; Watsa, Mrinalini; Tchamba, Martin N; Bourgeois, Stéphanie; Thouless, Chris; Douglas-Hamilton, Iain; Wittemyer, George; Van Coeverden de Groot, Peter J; Muwanika, Vincent B; Masembe, Charles; Georgiadis, Nicholas J; Hvilsom, Christina; Heller, Rasmus; Siegismund, Hans Redlef; Roca, Alfred L

ATPγS substantially defeats the biasing mechanism for kinesin steps

ATPγS 显著抑制了驱动蛋白步态的偏向机制

Karnawat, Vishakha; Toleikis, Algirdas; Carter, Nicholas J; Molloy, Justin E; Cross, Robert A

Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity

EZH2与DNA甲基化之间的相互作用介导神经内分泌前列腺癌谱系可塑性

Singh, Richa; Venkadakrishnan, Varadha Balaji; Imada, Eddie; Yamada, Yasutaka; Brady, Nicholas J; Dunmore, Kate E; Garner, Richard; Booker, Matthew A; Hanratty, Brian; Haffner, Michael C; Tolstorukov, Michael Y; Marchionni, Luigi; Robinson, Brian D; Rickman, David S; Beltran, Himisha

ATRX loss couples genome instability at a G-rich repeat to dysregulation of human alpha-globin expression.

ATRX 的缺失导致富含 G 的重复序列处的基因组不稳定性与人类 α-珠蛋白表达失调有关。

Shen Yuqi, Gupta Kinam, Tan-Wong Sue Mei, Wen Sean, Fisher Christopher A, Tamon Liezel, Proudfoot Nicholas J, Gibbons Richard J, Higgs Douglas R

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Mechanisms of disassembly at the actin filament pointed and barbed ends

肌动蛋白丝尖端和带刺端的解聚机制

Palmer, Nicholas J; Boczkowska, Malgorzata; Rebowski, Grzegorz; Dominguez, Roberto