日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization

测试正常范围内甲状腺激素测量对人体代谢和疾病的因果作用:系统孟德尔随机化

Heba Alwan, Jian'an Luan, Alice Williamson, Julia Carrasco-Zanini, Isobel D Stewart, Nicholas J Wareham, Claudia Langenberg, Maik Pietzner

Multi-omic prediction of incident type 2 diabetes

型糖尿病发生的多组学预测

Julia Carrasco-Zanini, Maik Pietzner, Eleanor Wheeler, Nicola D Kerrison, Claudia Langenberg, Nicholas J Wareham

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

大规模表型推断和体内功能验证表明 ADAMTS14 是肥胖基因

Katherine A Kentistou, Jian'an Luan, Laura B L Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton

ANGPTL3 (Angiopoietin-Like 3) Preferentially Resides on High-Density Lipoprotein in the Human Circulation, Affecting Its Activity

ANGPTL3(血管生成素样 3)优先存在于人体循环中的高密度脂蛋白上,影响其活性

Jordan M Kraaijenhof, Tycho R Tromp, Nick S Nurmohamed, Laurens F Reeskamp, Marije Langenkamp, Johannes H M Levels, S Matthijs Boekholdt, Nicholas J Wareham, Menno Hoekstra, Erik S G Stroes, G Kees Hovingh, Aldo Grefhorst

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis

PCSK9 的基因和体外抑制与钙化性主动脉瓣狭窄

Nicolas Perrot, Vincenza Valerio, Donato Moschetta, S Matthijs Boekholdt, Christian Dina, Hao Yu Chen, Erik Abner, Andreas Martinsson, Hasanga D Manikpurage, Sidwell Rigade, Romain Capoulade, Elvira Mass, Marie-Annick Clavel, Thierry Le Tourneau, David Messika-Zeitoun, Nicholas J Wareham, James C En

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

人类MC4R功能获得性变异体表现出信号传导偏向性并能预防肥胖

Luca A Lotta ,Jacek Mokrosiński ,Edson Mendes de Oliveira ,Chen Li ,Stephen J Sharp ,Jian'an Luan ,Bas Brouwers ,Vikram Ayinampudi ,Nicholas Bowker ,Nicola Kerrison ,Vasileios Kaimakis ,Diana Hoult ,Isobel D Stewart ,Eleanor Wheeler ,Felix R Day ,John R B Perry ,Claudia Langenberg ,Nicholas J Wareham ,I Sadaf Farooqi

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition

MicroRNA-196a 将人体脂肪分布与脂肪组织细胞外基质组成联系起来

Catriona Hilton, Matt J Neville, Laura B L Wittemans, Marijana Todorcevic, Katherine E Pinnick, Sara L Pulit, Jian'an Luan, Agné Kulyté, Ingrid Dahlman, Nicholas J Wareham, Luca A Lotta, Peter Arner, Cecilia M Lindgren, Claudia Langenberg, Fredrik Karpe

Regional fat depot masses are influenced by protein-coding gene variants

区域脂肪库质量受蛋白质编码基因变异的影响

Matt J Neville, Laura B L Wittemans, Katherine E Pinnick, Marijana Todorčević, Risto Kaksonen, Kirsi H Pietiläinen, Jian'an Luan, Robert A Scott, Nicholas J Wareham, Claudia Langenberg, Fredrik Karpe

The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations

线粒体 DNA OriB 变异(16184-16193 多胞嘧啶束)与欧洲人群 2 型糖尿病的关联

Zheng Ye, Christopher Gillson, Matt Sims, Kay-Tee Khaw, Magdalena Plotka, Joanna Poulton, Claudia Langenberg, Nicholas J Wareham

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

使用基因型可选择的人类生物资源对自身免疫基因座 IL2RA 的细胞特异性蛋白质表型进行分析

Calliope A Dendrou, Vincent Plagnol, Erik Fung, Jennie H M Yang, Kate Downes, Jason D Cooper, Sarah Nutland, Gillian Coleman, Matthew Himsworth, Matthew Hardy, Oliver Burren, Barry Healy, Neil M Walker, Kerstin Koch, Willem H Ouwehand, John R Bradley, Nicholas J Wareham, John A Todd, Linda S Wicker