日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

种系 TP53 突变在肿瘤诊断前数年就会发生拷贝数增加

Nicholas Light, Mehdi Layeghifard #, Ayush Attery #, Vallijah Subasri, Matthew Zatzman, Nathaniel D Anderson, Rupal Hatkar, Sasha Blay, David Chen, Ana Novokmet, Fabio Fuligni, James Tran, Richard de Borja, Himanshi Agarwal, Larissa Waldman, Lisa M Abegglen, Daniel Albertson, Jonathan L Finlay, Jord

Signatures of copy number alterations in human cancer

人类癌症中拷贝数变异的特征

Christopher D Steele, Ammal Abbasi, S M Ashiqul Islam, Amy L Bowes, Azhar Khandekar, Kerstin Haase, Shadi Hames-Fathi, Dolapo Ajayi, Annelien Verfaillie, Pawan Dhami, Alex McLatchie, Matt Lechner, Nicholas Light, Adam Shlien, David Malkin, Andrew Feber, Paula Proszek, Tom Lesluyes, Fredrik Mertens, 

Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma

Myc 和 p53 缺失共同作用,导致脉络丛癌的形成

Jun Wang, Diana M Merino, Nicholas Light, Brian L Murphy, Yong-Dong Wang, Xiaohui Guo, Andrew P Hodges, Lianne Q Chau, Kun-Wei Liu, Girish Dhall, Shahab Asgharzadeh, Erin N Kiehna, Ryan J Shirey, Kim D Janda, Michael D Taylor, David Malkin, David W Ellison, Scott R VandenBerg, Charles G Eberhart, Ro

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

杂合人类 Pol ε 校对缺陷引发的爆发性突变积累是由错配修复抑制引起的

Karl P Hodel #, Richard de Borja #, Erin E Henninger #, Brittany B Campbell, Nathan Ungerleider, Nicholas Light, Tong Wu, Kimberly G LeCompte, A Yasemin Goksenin, Bruce A Bunnell, Uri Tabori, Adam Shlien, Zachary F Pursell

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

跨细胞谱系的等位基因表达图谱,以确定非编码 SNP 的影响

Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu-Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann-Christine Syvänen, Tomi Pastinen

Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping

通过高密度 ChIP 基因分型检测人类细胞中的等位基因染色质状态

Nicholas Light, Véronique Adoue, Bing Ge, Shu-Huang Chen, Tony Kwan, Tomi Pastinen

Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome

对表达的 SNP 进行分析,确定人类失活 X 染色体的表达程度

Allison M Cotton, Bing Ge, Nicholas Light, Veronique Adoue, Tomi Pastinen, Carolyn J Brown