日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

设计一种粘蛋白选择性蛋白酶,用于靶向降解癌症相关的粘蛋白

Kayvon Pedram #, D Judy Shon #, Gabrielle S Tender #, Natalia R Mantuano, Jason J Northey, Kevin J Metcalf, Simon P Wisnovsky, Nicholas M Riley, Giovanni C Forcina, Stacy A Malaker, Angel Kuo, Benson M George, Caitlyn L Miller, Kerriann M Casey, José G Vilches-Moure, Michael J Ferracane, Valerie M W

Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer

唾液酸化糖蛋白通过与前列腺癌中的 Siglec-7 和 Siglec-9 结合来抑制免疫细胞杀伤

Ru M Wen, Jessica C Stark, G Edward W Marti, Zenghua Fan, Aram Lyu, Fernando Jose Garcia Marques, Xiangyue Zhang, Nicholas M Riley, Sarah M Totten, Abel Bermudez, Rosalie Nolley, Hongjuan Zhao, Lawrence Fong, Edgar G Engleman, Sharon J Pitteri, Carolyn R Bertozzi, James D Brooks

The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation

糖免疫检查点受体Siglec-7与T细胞配体相互作用并调节T细胞活化。

Natalie Stewart ,John Daly ,Olivia Drummond-Guy ,Vignesh Krishnamoorthy ,Jessica C Stark ,Nicholas M Riley ,Karla C Williams ,Carolyn R Bertozzi ,Simon Wisnovsky

Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies

乳腺癌脑转移中的癌-基质细胞相互作用诱导糖萼介导的对 HER2 靶向疗法的耐药性

Marie-Anne Goyette #, Laura E Stevens #, Carolyn R DePinho, Marco Seehawer, Jun Nishida, Zheqi Li, Callahan M Wilde, Rong Li, Xintao Qiu, Alanna L Pyke, Stephanie Zhao, Klothilda Lim, Gabrielle S Tender, Jason J Northey, Nicholas M Riley, Henry W Long, Carolyn R Bertozzi, Valerie M Weaver, Kornelia

Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras

阐明溶酶体靶向嵌合体靶向膜蛋白降解的细胞决定因素

Green Ahn, Nicholas M Riley, Roarke A Kamber, Simon Wisnovsky, Salvador Moncayo von Hase, Michael C Bassik, Steven M Banik, Carolyn R Bertozzi

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

小鼠运动训练的全身性、细胞类型特异性分泌组图谱分析

Wei Wei ,Nicholas M Riley ,Xuchao Lyu ,Xiaotao Shen ,Jing Guo ,Steffen H Raun ,Meng Zhao ,Maria Dolores Moya-Garzon ,Himanish Basu ,Alan Sheng-Hwa Tung ,Veronica L Li ,Wentao Huang ,Amanda L Wiggenhorn ,Katrin J Svensson ,Michael P Snyder ,Carolyn R Bertozzi ,Jonathan Z Long

Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity

突变筛选结果表明,糖基化是集落刺激因子3受体(CSF3R)活性的调节因子。

Michael J Hollander,Stacy A Malaker,Nicholas M Riley,Idalia Perez,Nayla M Abney,Melissa A Gray,Julia E Maxson,Jennifer R Cochran,Carolyn R Bertozzi

The microenvironment dictates glycocalyx construction and immune surveillance

微环境决定糖萼的构建和免疫监视

Kevin M Tharp, Sangwoo Park, Greg A Timblin, Alicia L Richards, Jordan A Berg, Nicholas M Twells, Nicholas M Riley, Egan L Peltan, D Judy Shon, Erica Stevenson, Kimberly Tsui, Francesco Palomba, Austin E Y T Lefebvre, Ross W Soens, Nadia M E Ayad, Johanna Ten Hoeve-Scott, Kevin Healy, Michelle Digma

Revealing the human mucinome

揭示人类粘蛋白组

Stacy A Malaker #, Nicholas M Riley #, D Judy Shon, Kayvon Pedram, Venkatesh Krishnan, Oliver Dorigo, Carolyn R Bertozzi

Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses

针对多发性骨髓瘤中的高唾液酸化是增强 NK 细胞介导的肿瘤反应的一种新方法

John Daly, Subhashis Sarkar, Alessandro Natoni, Jessica C Stark, Nicholas M Riley, Carolyn R Bertozzi, Mattias Carlsten, Michael E O'Dwyer