日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Structure guided studies of the interaction between PTP1B and JAK

PTP1B 与 JAK 相互作用的结构指导研究

Rhiannon Morris, Narelle Keating, Cyrus Tan, Hao Chen, Artem Laktyushin, Tamanna Saiyed, Nicholas P D Liau, Nicos A Nicola, Tony Tiganis, Nadia J Kershaw, Jeffrey J Babon

Structural basis for SHOC2 modulation of RAS signalling

SHOC2 调节 RAS 信号的结构基础

Nicholas P D Liau, Matthew C Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M Bruning, Timothy J Wendorff, Wilson Phung, Sarah G Hymowitz, Jawahar Sudhamsu0

CRAF dimerization with ARAF regulates KRAS-driven tumor growth

CRAF 与 ARAF 二聚化调节 KRAS 驱动的肿瘤生长

Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B Hinkle, David Kan, Ehud Segal, Jason E Long, Tony Lima, Nicholas P D Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R Junttila, Andrey S Shaw, Ma

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

野生型和突变型 Janus 激酶 1 的酶学特性

Liau, Nicholas P D; Laktyushin, Artem; Morris, Rhiannon; Sandow, Jarrod J; Nicola, Nicos A; Kershaw, Nadia J; Babon, Jeffrey J

The molecular basis of JAK/STAT inhibition by SOCS1

SOCS1 抑制 JAK/STAT 的分子基础

Nicholas P D Liau, Artem Laktyushin, Isabelle S Lucet, James M Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

JAK 活化环磷酸化的积累与骨髓纤维化中的 I 型 JAK 抑制剂戒断综合征有关

Denis Tvorogov, Daniel Thomas, Nicholas P D Liau, Mara Dottore, Emma F Barry, Maya Lathi, Winnie L Kan, Timothy R Hercus, Frank Stomski, Timothy P Hughes, Vinay Tergaonkar, Michael W Parker, David M Ross, Ravindra Majeti, Jeffrey J Babon, Angel F Lopez

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

通过生化和结构分析,深入了解骨髓增生性肿瘤相关JAK2突变体的激活和SOCS3介导的抑制机制

Varghese, Leila N; Ungureanu, Daniela; Liau, Nicholas P D; Young, Samuel N; Laktyushin, Artem; Hammaren, Henrik; Lucet, Isabelle S; Nicola, Nicos A; Silvennoinen, Olli; Babon, Jeffrey J; Murphy, James M

SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition

SOCS3 与特定的受体-JAK 复合物结合,通过直接抑制激酶来控制细胞因子信号传导。

Kershaw, Nadia J; Murphy, James M; Liau, Nicholas P D; Varghese, Leila N; Laktyushin, Artem; Whitlock, Eden L; Lucet, Isabelle S; Nicola, Nicos A; Babon, Jeffrey J