INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties
INX-08189 是 6-O-甲基-2'-C-甲基鸟苷的磷酸酰胺前药,是一种有效的丙型肝炎病毒复制抑制剂,具有优异的药代动力学和药效学特性
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/AAC.01335-10
John H Vernachio, Blair Bleiman, K Dawn Bryant, Stanley Chamberlain, Damound Hunley, Jeff Hutchins, Brenda Ames, Elena Gorovits, Babita Ganguly, Andrea Hall, Alexander Kolykhalov, Yule Liu, Jerry Muhammad, Nicholas Raja, C Robin Walters, Jin Wang, Karen Williams, Joseph M Patti, Geoffrey Henson, Kar