Nicholas W Morrell相关文献与解析，生知库

Bin Liu, Mujahid Azfar, Ekaterina Legchenko, James A West, Shaun Martin, Chris Van den Haute, Veerle Baekelandt, John Wharton, Luke Howard, Martin R Wilkins, Peter Vangheluwe, Nicholas W Morrell, Paul D Upton

心血管

肺动脉高压

发表日期：2024

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Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

与肺动脉高压相关的 EIF2AK4 (GCN2) 错义变异的功能验证

期刊:Human Molecular Genetics

影响因子:3.1

doi:10.1093/hmg/ddae082

Giulia Emanuelli, JiaYi Zhu, Wei Li, Nicholas W Morrell, Stefan J Marciniak

信号转导

发表日期：2024

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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension

SOX17 增强子变体破坏转录因子结合，增强子不活性导致肺动脉高压

期刊:Circulation

影响因子:35.5

doi:10.1161/CIRCULATIONAHA.122.061940

Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Olin D Liang, Ali Ashek, Olivier Dubois, Lin Zhao, Farah Sabrin, Inês Cebola, Jorge Ferrer, Nicholas W Morrell, James R Klinger, Martin R Wilkins, Lan Zhao #, Christopher J Rhodes #

信号转导

发表日期：2023

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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

高浓度的可溶性内皮糖蛋白可以抑制非内皮细胞中的 BMP9 信号传导

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-023-33352-3

Clara Andersson-Rusch #, Bin Liu #, Ingrid Quist-Løkken, Paul D Upton, Oddrun Elise Olsen, Hanne Hella, Xudong Yang, Zhen Tong, Nicholas W Morrell, Toril Holien, Wei Li

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

通过抑制综合应激反应逆转肺静脉闭塞性疾病表型

期刊:

影响因子:

doi:10.1101/2023.11.27.568924

Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Prajakta Ghatpande, Jingkun Zhang, Ziwen Zhao, Carlos O Lizama, Bhushan N Kharbikar, Stefan Gräf, Carmen M Treacy, Nicholas W Morrell, Brian B Graham, Giorgio Lagna, Akiko Hata

信号转导

发表日期：2023

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Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes

单细胞 RNA 测序揭示 BMPR2 突变通过 ID 基因调节右心室功能

期刊:European Respiratory Journal

影响因子:16.6

doi:10.1183/13993003.00327-2021

Mingxia Du, Haibin Jiang, Hongxian Liu, Xin Zhao, Yu Zhou, Fang Zhou, Chunmei Piao, Guoqiang Xu, Feng Ma, Jianan Wang, Frederic Perros, Nicholas W Morrell, Hong Gu, Jun Yang

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

BMPRII 胞外结构域与 BMP10 的二元和三元受体复合物的晶体结构

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-022-30111-2

Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M Salmon, Randy J Read, Peter Ten Dijke, Nicholas W Morrell, Wei Li

信号转导

发表日期：2022

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Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival

BMPR2 突变阳性患者与无突变肺动脉高压患者的不同细胞因子模式及其对生存的影响

期刊:Chest

影响因子:9.5

doi:10.1016/j.chest.2022.01.019

Max Schwiening, Emilia M Swietlik, Divya Pandya, Keith Burling, Peter Barker, Oliver Y Feng, Carmen M Treacy, Susana Abreu, S John Wort, Joanna Pepke-Zaba, Stefan Graf, Stefan J Marciniak, Nicholas W Morrell, Elaine Soon

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach

使用共识机器学习方法诊断肺动脉高压的 miRNA 特征

期刊:EBioMedicine

影响因子:9.7

doi:10.1016/j.ebiom.2021.103444

Niamh Errington, James Iremonger, Josephine A Pickworth, Sokratis Kariotis, Christopher J Rhodes, Alexander Mk Rothman, Robin Condliffe, Charles A Elliot, David G Kiely, Luke S Howard, John Wharton, A A Roger Thompson, Nicholas W Morrell, Martin R Wilkins, Dennis Wang, Allan Lawrie

Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an "HHT-like" syndrome in children

GDF2基因纯合无义突变会导致循环中BMP9和BMP10的缺失，并与儿童肺动脉高压（PAH）或“遗传性出血性毛细血管扩张症样”综合征相关。

期刊:Molecular Genetics & Genomic Medicine

影响因子:1.5

doi:10.1002/mgg3.1685

Joshua Hodgson，Lidia Ruiz-Llorente ，Jamie McDonald，Oliver Quarrell，Kelechi Ugonna，James Bentham，Rebecca Mason，Jennifer Martin，David Moore，Katie Bergstrom，Pinar Bayrak-Toydemir，Whitney Wooderchak-Donahue，Nicholas W Morrell，Robin Condliffe，Carmelo Bernabeu，Paul D Upton

ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport

ATP13A3 变体通过破坏多胺转运促进肺动脉高压

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

与肺动脉高压相关的 EIF2AK4 (GCN2) 错义变异的功能验证

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension

SOX17 增强子变体破坏转录因子结合，增强子不活性导致肺动脉高压

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

高浓度的可溶性内皮糖蛋白可以抑制非内皮细胞中的 BMP9 信号传导

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

通过抑制综合应激反应逆转肺静脉闭塞性疾病表型

Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes

单细胞 RNA 测序揭示 BMPR2 突变通过 ID 基因调节右心室功能

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

BMPRII 胞外结构域与 BMP10 的二元和三元受体复合物的晶体结构

Different Cytokine Patterns in BMPR2-Mutation-Positive Patients and Patients With Pulmonary Arterial Hypertension Without Mutations and Their Influence on Survival

BMPR2 突变阳性患者与无突变肺动脉高压患者的不同细胞因子模式及其对生存的影响

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach

使用共识机器学习方法诊断肺动脉高压的 miRNA 特征

Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an "HHT-like" syndrome in children

GDF2基因纯合无义突变会导致循环中BMP9和BMP10的缺失，并与儿童肺动脉高压（PAH）或“遗传性出血性毛细血管扩张症样”综合征相关。