日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tau protein profiling in tauopathies: a human brain study

tau蛋白病中tau蛋白谱分析:一项人脑研究

Juan Lantero-Rodriguez # ,Elena Camporesi # ,Laia Montoliu-Gaya ,Johan Gobom ,Diana Piotrowska ,Maria Olsson ,Irena Matečko Burmann ,Bruno Becker ,Ann Brinkmalm ,Björn M Burmann ,Michael Perkinton ,Nicholas J Ashton ,Nick C Fox ,Tammaryn Lashley ,Henrik Zetterberg ,Kaj Blennow # ,Gunnar Brinkmalm #

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

早老素1基因P436S突变会导致家族性阿尔茨海默病,伴有Aβ43升高和非典型临床表现。

Charles Arber ,Christopher R S Belder ,Filip Tomczuk ,Rebecca Gabriele ,Yazead Buhidma ,Clíona Farrell ,Antoinette O'Connor ,Helen Rice ,Tammaryn Lashley ,Nick C Fox ,Natalie S Ryan ,Selina Wray

Biomarker clustering in autosomal dominant Alzheimer's disease

常染色体显性阿尔茨海默病的生物标志物聚集

Patrick H Luckett, Charlie Chen, Brian A Gordon, Julie Wisch, Sarah B Berman, Jasmeer P Chhatwal, Carlos Cruchaga, Anne M Fagan, Martin R Farlow, Nick C Fox, Mathias Jucker, Johannes Levin, Colin L Masters, Hiroshi Mori, James M Noble, Stephen Salloway, Peter R Schofield, Adam M Brickman, William S

Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset

阿尔茨海默病引起的 PSEN1 变异产生的 Aβ 谱可确定突变的致病性并预测发病年龄

Dieter Petit #, Sara Gutiérrez Fernández #, Katarzyna Marta Zoltowska, Thomas Enzlein, Natalie S Ryan, Antoinette O'Connor, Maria Szaruga, Elizabeth Hill, Rik Vandenberghe, Nick C Fox, Lucía Chávez-Gutiérrez

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

PSEN1 E280G突变导致诱导多能干细胞神经元中β-淀粉样蛋白43的产生增加,并在脑组织中沉积。

Nanet Willumsen ,Charles Arber ,Christopher Lovejoy ,Jamie Toombs ,Argyro Alatza ,Philip S J Weston ,Lucia Chávez-Gutiérrez ,John Hardy ,Henrik Zetterberg ,Nick C Fox ,Natalie S Ryan ,Tammaryn Lashley ,Selina Wray

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70

在英国一项针对70岁出生队列的人群中开展基于人群的阿尔茨海默病临床前期血液筛查

Ashvini Keshavan ,Josef Pannee ,Thomas K Karikari ,Juan Lantero Rodriguez ,Nicholas J Ashton ,Jennifer M Nicholas ,David M Cash ,William Coath ,Christopher A Lane ,Thomas D Parker ,Kirsty Lu ,Sarah M Buchanan ,Sarah E Keuss ,Sarah-Naomi James ,Heidi Murray-Smith ,Andrew Wong ,Anna Barnes ,John C Dickson ,Amanda Heslegrave ,Erik Portelius ,Marcus Richards ,Nick C Fox ,Henrik Zetterberg ,Kaj Blennow ,Jonathan M Schott

Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

PSEN1基因的家族性阿尔茨海默病突变导致人类干细胞过早发生神经发生

Charles Arber ,Christopher Lovejoy ,Lachlan Harris ,Nanet Willumsen ,Argyro Alatza ,Jackie M Casey ,Georgie Lines ,Caoimhe Kerins ,Anika K Mueller ,Henrik Zetterberg ,John Hardy ,Natalie S Ryan ,Nick C Fox ,Tammaryn Lashley ,Selina Wray

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

家族性阿尔茨海默病患者来源的神经元揭示了特定突变对β-淀粉样蛋白的独特影响。

Charles Arber # ,Jamie Toombs # ,Christopher Lovejoy ,Natalie S Ryan ,Ross W Paterson ,Nanet Willumsen ,Eleni Gkanatsiou ,Erik Portelius ,Kaj Blennow ,Amanda Heslegrave ,Jonathan M Schott ,John Hardy ,Tammaryn Lashley ,Nick C Fox ,Henrik Zetterberg # ,Selina Wray #

Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy

脑淀粉样血管病的脑脊液生物标志物

Gargi Banerjee, Gareth Ambler, Ashvini Keshavan, Ross W Paterson, Martha S Foiani, Jamie Toombs, Amanda Heslegrave, John C Dickson, Francesco Fraioli, Ashley M Groves, Michael P Lunn, Nick C Fox, Henrik Zetterberg, Jonathan M Schott, David J Werring

CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia

非典型阿尔茨海默病患者的脑脊液突触蛋白浓度升高,但额颞叶痴呆患者的脑脊液突触蛋白浓度不升高

Mica T M Clarke, Ann Brinkmalm, Martha S Foiani, Ione O C Woollacott, Carolin Heller, Amanda Heslegrave, Ashvini Keshavan, Nick C Fox, Jonathan M Schott, Jason D Warren, Kaj Blennow, Henrik Zetterberg, Jonathan D Rohrer