日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

PKC 同工型通过磷酸化 CORB GTPase 结构域内的保守残基 (Ser1064、Ser1074 和 Thr1075) 来激活 LRRK1 激酶

Asad U Malik #, Athanasios Karapetsas #, Raja S Nirujogi, Deep Chatterjee, Toan K Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R Alessi

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

LPP3 介导黑色素瘤细胞自身产生趋化性 LPA 梯度

Olivia Susanto, Yvette W H Koh, Nick Morrice, Sergey Tumanov, Peter A Thomason, Matthew Nielson, Luke Tweedy, Andrew J Muinonen-Martin, Jurre J Kamphorst, Gillian M Mackay, Robert H Insall

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

KA1靶向调节域突变在没有DNA损伤的情况下激活Chk1

Eun-Yeung Gong, Veronique A J Smits, Felipe Fumagallo, Desiree Piscitello, Nick Morrice, Raimundo Freire, David A Gillespie

Quantitative fragmentome mapping reveals novel, domain-specific partners for the modular protein RepoMan (recruits PP1 onto mitotic chromatin at anaphase)

定量碎片组图谱揭示了模块化蛋白质 RepoMan 的新型域特异性伙伴(在后期将 PP1 招募到有丝分裂染色质上)

Michèle Prévost, Delphine Chamousset, Isha Nasa, Emily Freele, Nick Morrice, Greg Moorhead, Laura Trinkle-Mulcahy

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573

确定 IRS-2 的 300-600 位氨基酸为 14-3-3 结合区,并确定 Ser-573 位点的磷酸化对 IGF-1/胰岛素调节的重要性

Sabine S Neukamm, Rachel Toth, Nick Morrice, David G Campbell, Carol Mackintosh, Rainer Lehmann, Hans-Ulrich Haering, Erwin D Schleicher, Cora Weigert

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21

人类有丝分裂蛋白磷酸酶复合物的分离:蛋白磷酸酶 1 与 RNA 解旋酶 Ddx21 之间的复合物的鉴定

Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

磷酸化蛋白质组学分析揭示了调控组蛋白去乙酰化酶 7 的内在途径,从而控制细胞毒性 T 淋巴细胞的功能

Maria N Navarro, Jurgen Goebel, Carmen Feijoo-Carnero, Nick Morrice, Doreen A Cantrell

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)

IRAK1 和 IRAK4 促进 MyD88 适配器样 (Mal) 的磷酸化、泛素化和降解

Aisling Dunne, Susan Carpenter, Constantinos Brikos, Pearl Gray, Astrid Strelow, Holger Wesche, Nick Morrice, Luke A J O'Neill

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

Exo1 的检查点依赖性磷酸化调节 DNA 损伤反应

Isabelle Morin, Hien-Ping Ngo, Amanda Greenall, Mikhajlo K Zubko, Nick Morrice, David Lydall

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

IRAK 催化激活 Pellino 异构体的 E3 连接酶功能,诱导 IRAK1 发生 Lys63 连接的多泛素化

Alban Ordureau, Hilary Smith, Mark Windheim, Mark Peggie, Emma Carrick, Nick Morrice, Philip Cohen