日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology

一种能穿透血脑屏障的P2X7R拮抗剂可减轻阿尔茨海默病病理。

Turcu, Andreea L; Oken, Adam C; Griñán-Ferré, Christian; Durner, Anna; Sierra-Marquez, Juan; Hinz-Kowalik, Sonja; Nagel, Jessica; Lee, So-Deok; Tzortzini, Efpraxia; Georgiou, Kyriakos; Bhol, Mamina; Baz, Zuriñe; Llop, Jordi; Schneider, Marion; Barbaraci, Carla; Kim, Ga-Ram; Barniol-Xicota, Marta; Val, Cristina; Brea, José; Loza, M Isabel; Pérez, Belén; Naesens, Lieve; Kolocouris, Antonios; Kim, Yong-Chul; Müller, Christa E; Nicke, Annette; Pallàs, Mercè; Mansoor, Steven E; Vázquez, Santiago

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor

基于结构的药物设计鉴定出的一种多环骨架能有效抑制人P2X7受体。

Oken, Adam C; Turcu, Andreea L; Tzortzini, Eva; Georgiou, Kyriakos; Nagel, Jessica; Westermann, Franka G; Barniol-Xicota, Marta; Seidler, Jonas; Kim, Ga-Ram; Lee, So-Deok; Nicke, Annette; Kim, Yong-Chul; Müller, Christa E; Kolocouris, Antonios; Vázquez, Santiago; Mansoor, Steven E

Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor

在人P2X4受体上发现蒽醌的变构结合位点

Nagel, Jessica; Namasivayam, Vigneshwaran; Weinhausen, Stephanie; Sierra-Marquez, Juan; Baqi, Younis; Al Musawi, Hashem Ali M; Abdelrahman, Aliaa; Vaaßen, Victoria J; Schlegel, Jonathan G; Taplick, Lisa; Torp, Jane; Kubicek, Jan; Maertens, Barbara; Geyer, Matthias; Claff, Tobias; Nicke, Annette; Hagelueken, Gregor; Müller, Christa E

Call for Papers – Purinergic Signaling: Medicinal Chemistry, Biology, Pharmacology, and Translation into Diagnostic and Therapeutic Drugs

征稿启事——嘌呤能信号传导:药物化学、生物学、药理学及其在诊断和治疗药物中的转化应用

Yang, Song; Sun, Yiran; Yan, Chenchen; Müller, Christa E; Nicke, Annette; Lohr, Christian; Freichel, Marc; Guse, Andreas H

ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation.

肾内炎症中肾脏驻留自然杀伤T细胞和记忆T细胞上的ATP门控P2X7离子通道

Junge Marten, Liaukouskaya Nastassia, Schwarz Nicole, Pinto-Espinoza Carolina, Schaffrath Alessa Z, Rissiek Björn, Krebs Christian F, Rattay Guido, Mittrücker Hans-Willi, Tomas Nicola M, Nicke Annette, Haag Friedrich, Huber Tobias B, Meyer-Schwesinger Catherine, Koch-Nolte Friedrich, Wanner Nicola

Genetic Deletion of the Purinergic Receptor P2rx7 Worsens the Phenotype of α‑Sarcoglycan Muscular Dystrophy

嘌呤能受体P2rx7基因缺失会加重α-肌聚糖型肌营养不良症的表型

Astigiano, Cecilia; Principi, Elisa; Pintus, Sara; Benzi, Andrea; Baratto, Serena; Panicucci, Chiara; Passalacqua, Mario; Sierra-Marquez, Juan; Nicke, Annette; Antonini, Francesca; Del Zotto, Genny; Cicatiello, Annunziata Gaetana; Raffaghello, Lizzia; Rezzonico Jost, Tanja; Grassi, Fabio; Bruzzone, Santina; Bruno, Claudio; Gazzerro, Elisabetta

Symmetrical Bispyridinium Compounds Act as Open Channel Blockers of Cation-Selective Ion Channels

对称双吡啶化合物作为阳离子选择性离子通道的开放通道阻滞剂

Haufe, Yves; Loser, Dominik; Danker, Timm; Nicke, Annette

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

2023/24版简明药理学指南:离子通道

Alexander, Stephen P H; Mathie, Alistair A; Peters, John A; Veale, Emma L; Striessnig, Jörg; Kelly, Eamonn; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Davies, Jamie A; Aldrich, Richard W; Attali, Bernard; Baggetta, Austin M; Becirovic, Elvir; Biel, Martin; Bill, Roslyn M; Caceres, Ana I; Catterall, William A; Conner, Alex C; Davies, Paul; De Clerq, Katrien; Delling, Markus; Di Virgilio, Francesco; Falzoni, Simonetta; Fenske, Stefanie; Fortuny-Gomez, Anna; Fountain, Samuel; George, Chandy; Goldstein, Steve A N; Grimm, Christian; Grissmer, Stephan; Ha, Kotdaji; Hammelmann, Verena; Hanukoglu, Israel; Hu, Meiqin; Ijzerman, Ad P; Jabba, Sairam V; Jarvis, Mike; Jensen, Anders A; Jordt, Sven E; Kaczmarek, Leonard K; Kellenberger, Stephan; Kennedy, Charles; King, Brian; Kitchen, Philip; Liu, Qiang; Lynch, Joseph W; Meades, Jessica; Mehlfeld, Verena; Nicke, Annette; Offermanns, Stefan; Perez-Reyes, Edward; Plant, Leigh D; Rash, Lachlan; Ren, Dejian; Salman, Mootaz M; Sieghart, Werner; Sivilotti, Lucia G; Smart, Trevor G; Snutch, Terrance P; Tian, Jinbin; Trimmer, James S; Van den Eynde, Charlotte; Vriens, Joris; Wei, Aguan D; Winn, Brenda T; Wulff, Heike; Xu, Haoxing; Yang, Fan; Fang, Wei; Yue, Lixia; Zhang, Xiaoli; Zhu, Michael

P2X7 receptor inhibition ameliorates ubiquitin-proteasome system dysfunction associated with Alzheimer's disease

P2X7受体抑制可改善与阿尔茨海默病相关的泛素-蛋白酶体系统功能障碍

Bianchi, Carolina; Alvarez-Castelao, Beatriz; Sebastián-Serrano, Álvaro; Di Lauro, Caterina; Soria-Tobar, Lucia; Nicke, Annette; Engel, Tobias; Díaz-Hernández, Miguel

Increased uptake of the P2X7 receptor radiotracer (18) F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice

雄性小鼠癫痫持续状态严重程度与脑和外周器官中 P2X7 受体放射性示踪剂 (18) F-JNJ-64413739 的摄取量增加相关。

Morgan, James; Moreno, Oscar; Alves, Mariana; Baz, Zuriñe; Menéndez Méndez, Aida; Leister, Hanna; Melia, Ciara; Smith, Jonathon; Visekruna, Alexander; Nicke, Annette; Bhattacharya, Anindya; Ceusters, Marc; Henshall, David C; Gómez-Vallejo, Vanessa; Llop, Jordi; Engel, Tobias