日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peptides blocking ApoE pathological function safely reduce pathology in TgSwDI/apoE2, 3 and 4 AD mice

阻断ApoE病理功能的肽类药物可安全地减轻TgSwDI/apoE2、3和4型阿尔茨海默病小鼠的病理症状。

Muench, Nicole A; Patel, Sonia; Maes, Margaret E; Donahue, Ryan J; Ikeda, Akihiro; Nickells, Robert W; Goni, Fernando; Wang, Ding; Suazo, Jianina; Lin, Jasmine; Okeagu, Jasmine; Gamallo‐Lana, Begonia; Mar, Adam; Wisniewski, Thomas

Intravitreal AAV2 gene delivery to feline retinal ganglion cells

玻璃体内 AAV2 基因递送至猫视网膜神经节细胞

Kazuya Oikawa, J Seth Eaton, Julie A Kiland, Odalys Torné, Virginia Mathu, Robert W Nickells, Gillian J McLellan

Cytoprotective Small Compound M109S Attenuated Retinal Ganglion Cell Degeneration Induced by Optic Nerve Crush in Mice

细胞保护性小化合物 M109S 减轻小鼠视神经挤压引起的视网膜神经节细胞变性

Jonah J Scott-McKean, Mieko Matsuyama, Charles W Guo, Lin Ni, Brandon Sassouni, Shree Kurup, Robert Nickells, Shigemi Matsuyama

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

小鼠视网膜神经节细胞中的 BAX 激活发生在两个时间和机制上不同的步骤中

Margaret E Maes #, Ryan J Donahue #, Cassandra L Schlamp, Olivia J Marola, Richard T Libby, Robert W Nickells

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

小鼠视网膜神经节细胞中的 BAX 激活发生在两个时间和机制上不同的步骤中

Margaret E Maes, Ryan J Donahue, Cassandra L Schlamp, Olivia J Marola, Richard T Libby, Robert Nickells

BclX(L) (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury

BclX(L) (Bcl2l1) 基因疗法可减轻急性轴突损伤后视网膜神经节细胞胞体丢失,但不能减轻轴突变性

Marola, Olivia J; Yablonski, Sarah E R; Shrager, Peter G; Nickells, Robert W; Libby, Richard T

BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma

BCLXL 基因疗法可缓解 DBA/2J 遗传性青光眼小鼠模型中的神经病理学

Ryan J Donahue, Rachel L Fehrman, Jenna R Gustafson, Robert W Nickells

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis

细胞凋亡过程中线粒体BAX募集的细胞内传播特征

Grosser, Joshua A; Maes, Margaret E; Nickells, Robert W

Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression

诱导 HDAC3 表达可增加神经元的易感性和内在凋亡信号

Heather M Schmitt, Rachel L Fehrman, Margaret E Maes, Huan Yang, Lian-Wang Guo, Cassandra L Schlamp, Heather R Pelzel, Robert W Nickells

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis

线粒体靶向肽(elamipretide/SS31)对细胞凋亡过程中BAX募集和激活的影响

Grosser, Joshua A; Fehrman, Rachel L; Keefe, Dennis; Redmon, Martin; Nickells, Robert W