日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peptides blocking ApoE pathological function safely reduce pathology in TgSwDI/apoE2, 3 and 4 AD mice

阻断ApoE病理功能的肽类药物可安全地减轻TgSwDI/apoE2、3和4型阿尔茨海默病小鼠的病理症状。

Muench, Nicole A; Patel, Sonia; Maes, Margaret E; Donahue, Ryan J; Ikeda, Akihiro; Nickells, Robert W; Goni, Fernando; Wang, Ding; Suazo, Jianina; Lin, Jasmine; Okeagu, Jasmine; Gamallo‐Lana, Begonia; Mar, Adam; Wisniewski, Thomas

Contralateral Astrocyte Response to Acute Optic Nerve Damage Is Mitigated by PANX1 Channel Activity

PANX1通道活性可减轻对侧星形胶质细胞对急性视神经损伤的反应。

Wurl, Jasmine A; Mac Nair, Caitlin E; Dietz, Joel A; Shestopalov, Valery I; Nickells, Robert W

BclX(L) (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury

BclX(L) (Bcl2l1) 基因疗法可减轻急性轴突损伤后视网膜神经节细胞胞体丢失,但不能减轻轴突变性

Marola, Olivia J; Yablonski, Sarah E R; Shrager, Peter G; Nickells, Robert W; Libby, Richard T

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis

细胞凋亡过程中线粒体BAX募集的细胞内传播特征

Grosser, Joshua A; Maes, Margaret E; Nickells, Robert W

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis

线粒体靶向肽(elamipretide/SS31)对细胞凋亡过程中BAX募集和激活的影响

Grosser, Joshua A; Fehrman, Rachel L; Keefe, Dennis; Redmon, Martin; Nickells, Robert W

Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma

在DBA/2J自发性青光眼小鼠模型中靶向HDAC3

Schmitt, Heather M; Grosser, Joshua A; Schlamp, Cassandra L; Nickells, Robert W

Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury

利用RGFP966靶向HDAC3活性可保护视神经损伤后的视网膜神经节细胞免受核萎缩和凋亡的影响

Schmitt, Heather M; Schlamp, Cassandra L; Nickells, Robert W

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

BAX基础知识:BCL2基因家族如何控制视网膜神经节细胞的死亡

Maes, Margaret E; Schlamp, Cassandra L; Nickells, Robert W

Negative regulators of angiogenesis: important targets for treatment of exudative AMD

血管生成负调控因子:渗出性年龄相关性黄斑变性治疗的重要靶点。

Farnoodian, Mitra; Wang, Shoujian; Dietz, Joel; Nickells, Robert W; Sorenson, Christine M; Sheibani, Nader

Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways

在缺乏Bax蛋白的小鼠中,视网膜胶质细胞对视神经挤压的反应减弱,并受嘌呤能信号通路调节。

Mac Nair, Caitlin E; Schlamp, Cassandra L; Montgomery, Angela D; Shestopalov, Valery I; Nickells, Robert W