日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

NOTCH3 靶向抗体药物偶联物通过诱导受体细胞凋亡和通过内吞作用进入配体细胞来消退肿瘤

Kenneth G Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christophe

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

建立体内外相关性,筛选与有利的人体药代动力学相关的物理化学特性的单克隆抗体

Lindsay B Avery, Jason Wade, Mengmeng Wang, Amy Tam, Amy King, Nicole Piche-Nicholas, Mania S Kavosi, Steve Penn, David Cirelli, Jeffrey C Kurz, Minlei Zhang, Orla Cunningham, Rhys Jones, Brian J Fennell, Barry McDonnell, Paul Sakorafas, James Apgar, William J Finlay, Laura Lin, Laird Bloom, Denise

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

通过与抗 HSA 鲨鱼 VNAR 结构域融合来改善生物制剂的药代动力学特性

Mischa R Müller, Kenneth Saunders, Christopher Grace, Macy Jin, Nicole Piche-Nicholas, John Steven, Ronan O'Dwyer, Leeying Wu, Lam Khetemenee, Yulia Vugmeyster, Timothy P Hickling, Lioudmila Tchistiakova, Stephane Olland, Davinder Gill, Allan Jensen, Caroline J Barelle