AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
由于 PTEN 缺失而激活的 AKT 通过 GSK3β/NRF2 上调 xCT,从而抑制 PTEN 突变肿瘤细胞中的铁死亡
期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2023.112536
Kaitlyn M Cahuzac, Abigail Lubin, Kaitlyn Bosch, Nicole Stokes, Sarah Mense Shoenfeld, Royce Zhou, Haddy Lemon, John Asara, Ramon E Parsons