Modeling response to the KRAS-G12C inhibitor AZD4625 in KRAS(G12C) NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms
在KRAS(G12C)非小细胞肺癌患者来源的异种移植模型中模拟KRAS-G12C抑制剂AZD4625的反应,揭示了原发性耐药机制的奥秘。
期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-03216-w
Rosen, Joshua C; Cao, Pinjiang; Pham, Nhu-An; Waas, Matthew; Li, Quan; Hueniken, Katrina; Wang, Mutian; Navab, Roya; Wybenga-Groot, Leanne; Radulovich, Nikolina; Niedbala, Michael; Koers, Alex; Ross, Sarah; Moran, Michael F; Sacher, Adrian; Tsao, Ming-Sound