日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting Casein Kinase 2 and Histone Deacetylase with a Dual Inhibitor Effectively Reduces Tumor Growth in a Triple-Negative Breast Cancer Xenograft Model.

在三阴性乳腺癌异种移植模型中，使用双重抑制剂靶向酪蛋白激酶 2 和组蛋白去乙酰化酶可有效减少肿瘤生长

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00192
Ortín Irene, Ochoa-Callejero Laura, Werner Christian, Lindenblatt Dirk, Niefind Karsten, Martínez Alfredo, de Pascual-Teresa Beatriz, Ramos Ana
肿瘤
乳腺癌
乙酰化
发表日期：2025
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Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E-/Z-Isomers.

发现 7,9-二溴二氢二苯并呋喃是一种有效的酪蛋白激酶 2 (CK2) 抑制剂：E-/Z-异构体的合成、生物学评价和结构研究

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.4c00426
Rumler Hendrik, Schmithals Claudia, Werner Christian, Bollacke Andre, Aichele Dagmar, Götz Claudia, Niefind Karsten, Wünsch Bernhard, Jose Joachim
免疫/内分泌
发表日期：2024
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A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4

来自葡萄（Vitis vinifera）的EDS1剪接变体可与PAD4形成同源二聚体，但不形成异源二聚体。

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.4624
Voss, Martin; Cseke, Leland J; Gassmann, Walter; Niefind, Karsten
发表日期：2023
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Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures

通过可靠的原子分辨率CK2α'结构解析方法探索CK2α旁系同源物对茚并吲哚抑制剂的重音符号结合

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.8b03415
Lindenblatt, Dirk; Nickelsen, Anna; Applegate, Violetta M; Hochscherf, Jennifer; Witulski, Benedict; Bouaziz, Zouhair; Marminon, Christelle; Bretner, Maria; Le Borgne, Marc; Jose, Joachim; Niefind, Karsten
发表日期：2019
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Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor

高度糖基化的人类白细胞弹性蛋白酶与S2'位点结合抑制剂复合物的晶体结构

期刊:Acta Crystallographica Section F-Structural Biology Communications
影响因子:1.1
doi:10.1107/S2053230X1800537X
Hochscherf, Jennifer; Pietsch, Markus; Tieu, William; Kuan, Kevin; Abell, Andrew D; Gütschow, Michael; Niefind, Karsten
细胞生物学
发表日期：2018
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Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

通过与黄酮醇类和噻吩并[2,3-d]嘧啶类抑制剂的复合物结构揭示了两种人类蛋白激酶CK2催化亚基旁系同源物的结构超变异性

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph10010009
Niefind, Karsten; Bischoff, Nils; Golub, Andriy G; Bdzhola, Volodymyr G; Balanda, Anatoliy O; Prykhod'ko, Andriy O; Yarmoluk, Sergiy M
信号转导
Human
发表日期：2017
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Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'

通过与催化亚基CK2α及其旁系同源物CK2α'的复合物结构，揭示了一种强效的茚并[1,2-b]吲哚类蛋白激酶CK2抑制剂的意外结合模式

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph10040098
Hochscherf, Jennifer; Lindenblatt, Dirk; Witulski, Benedict; Birus, Robin; Aichele, Dagmar; Marminon, Christelle; Bouaziz, Zouhair; Le Borgne, Marc; Jose, Joachim; Niefind, Karsten
信号转导
发表日期：2017
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Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101

拟南芥 EDS1（植物免疫的关键组分）与其信号伴侣 SAG101 复合物的结晶和初步晶体学分析

期刊:Acta Crystallographica Section F-Structural Biology and Crystallization Communications
影响因子:1.1
doi:10.1107/S1744309110051249
Wagner, Stephan; Rietz, Steffen; Parker, Jane E; Niefind, Karsten
信号转导
免疫/内分泌
发表日期：2011
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Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae

酿酒酵母中NADP(+)依赖性醇脱氢酶Gre2p的结晶及初步晶体学分析

期刊:Acta Crystallographica Section F-Structural Biology and Crystallization Communications
影响因子:1.1
doi:10.1107/S1744309110018889
Breicha, Klaus; Müller, Marion; Hummel, Werner; Niefind, Karsten
发表日期：2010
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Crystallization and preliminary crystallographic analysis of cgHle, a homoserine acetyltransferase homologue, from Corynebacterium glutamicum

谷氨酸棒状杆菌同源物 cgHle（一种高丝氨酸乙酰转移酶同源物）的结晶及初步晶体学分析

期刊:Acta Crystallographica Section F-Structural Biology and Crystallization Communications
影响因子:1.1
doi:10.1107/S1744309108039146
Tölzer, Christine; Pal, Sonia; Watzlawick, Hildegard; Altenbuchner, Josef; Niefind, Karsten
发表日期：2009
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