日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

白细胞介素-7受体α突变激活可启动前体B细胞急性淋巴细胞白血病。

Afonso R M Almeida,João L Neto,Ana Cachucho,Mayara Euzébio,Xiangyu Meng,Rathana Kim,Marta B Fernandes,Beatriz Raposo,Mariana L Oliveira,Daniel Ribeiro,Rita Fragoso,Priscila P Zenatti,Tiago Soares,Mafalda R de Matos,Juliana Ronchi Corrêa,Mafalda Duque,Kathryn G Roberts,Zhaohui Gu,Chunxu Qu,Clara Pereira,Susan Pyne,Nigel J Pyne,Vasco M Barreto,Isabelle Bernard-Pierrot,Emannuelle Clappier,Charles G Mullighan,Ana R Grosso,J Andrés Yunes #,João T Barata #

A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells

乳腺癌细胞鞘氨醇激酶1转位至质膜的新模型

Ryan D R Brown, Ben E P Veerman, Jeongah Oh, Rothwelle J Tate, Federico Torta, Margaret R Cunningham, David R Adams, Susan Pyne, Nigel J Pyne

Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds

二氢神经酰胺去饱和酶作为细胞凋亡的诱导剂和矫正剂:视黄醇衍生物、抗氧化剂和酚类化合物的作用

Mariam Alsanafi, Ryan D R Brown, Jeongah Oh, David R Adams, Federico Torta, Nigel J Pyne, Susan Pyne

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

鞘氨醇激酶 1 通过抑制 STAT1 来调节乳腺癌干细胞和非乳腺癌干细胞的存活

Ling-Wei Hii, Felicia Fei-Lei Chung, Chun Wai Mai, Zong Yang Yee, Hong Hao Chan, Vijay Joseph Raja, Noah Elias Dephoure, Nigel J Pyne, Susan Pyne, Chee-Onn Leong

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

鞘氨醇激酶对人胚胎肾细胞中 p53、p38 MAPK、JNK 和 XBP-1s 的调控

Mariam Alsanafi, Samuel L Kelly, Melissa McNaughton, Alfred H Merrill Jr, Nigel J Pyne, Susan Pyne

A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes

新型选择性鞘氨醇激酶 2 抑制剂 HWG-35D 通过阻断幼稚 CD4 T 淋巴细胞的 Th17 分化来改善咪喹莫特诱发的银屑病模型的严重程度

Sun-Hye Shin, Hee-Yeon Kim, Hee-Soo Yoon, Woo-Jae Park, David R Adams, Nigel J Pyne, Susan Pyne, Joo-Won Park

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

麻醉小鼠对花生四烯乙醇胺的降压反应第 1 阶段需要鞘氨醇激酶 1 介导

Fiona H Greig, Katrin Nather, Margaret D Ballantyne, Zeshan H Kazi, Husam Alganga, Marie-Ann Ewart, Karolina E Zaborska, Bracy Fertig, Nigel J Pyne, Susan Pyne, Simon Kennedy

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

鞘氨醇-1-磷酸受体-1对乳腺癌患者的预后有好坏之分吗?

Pyne, Nigel J; Pyne, Susan

Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival

二氢神经酰胺去饱和酶的天然形式和多泛素化形式与人类胚胎肾细胞存活存在差异

Mariam Alsanafi, Samuel L Kelly, Karawan Jubair, Melissa McNaughton, Rothwelle J Tate, Alfred H Merrill Jr, Susan Pyne, Nigel J Pyne

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

鞘氨醇 1-磷酸受体 2 在乳腺癌细胞的外泌体中脱落,并在 N 端加工成短的组成性活性形式,促进成纤维细胞中的细胞外信号调节激酶活化和 DNA 合成

Ashref El Buri, David R Adams, Douglas Smith, Rothwelle J Tate, Margaret Mullin, Susan Pyne, Nigel J Pyne