日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone

在 tau 蛋白病中,颗粒酶 A 对 tau 进行蛋白水解,产生易于聚集的碎片

James P Quinn, Kate Fisher, Nicola Corbett, Stacey Warwood, David Knight, Katherine A B Kellett, Nigel M Hooper

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

诱导性多能干细胞模型揭示遗传性小血管病中神经血管相互作用受损,伴有皮质下梗塞和白质脑病的常染色体显性脑动脉病

Wenjun Zhang, Xiangjun Zhao, Xuewei Qi, Susan J Kimber, Nigel M Hooper, Tao Wang

Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

肝细胞中低密度脂蛋白受体的蛋白水解由 BMP1 介导,而不是由其他虾红素蛋白酶介导

Katherine A B Kellett, Kate Fisher, Harry Aldworth, Nigel M Hooper

Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition

抑制人类神经元中的胰岛素降解酶可促进淀粉样β蛋白沉积

Helen A Rowland, Samuel R Moxon, Nicola J Corbett, Kelsey Hanson, Kate Fisher, Katherine A B Kellett, Nigel M Hooper

Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease

纳米粒子增强阿尔茨海默病纵向血液蛋白质组指纹富集

Marilena Hadjidemetriou, Jack Rivers-Auty, Lana Papafilippou, James Eales, Katherine A B Kellett, Nigel M Hooper, Catherine B Lawrence, Kostas Kostarelos

Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia

帕金森病痴呆和阿尔茨海默病痴呆患者普遍存在脑铜含量普遍下降的情况

Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M Hooper, Richard D Unwin, Garth J S Cooper

Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia

人类脑组织尿素严重且区域性广泛增加代表了帕金森病痴呆致病潜力的新发现

Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M Hooper, Richard D Unwin, Garth J S Cooper

Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome

利用常见遗传变异研究22q11.2缺失综合征的表型表达和风险预测

Davies, Robert W; Fiksinski, Ania M; Breetvelt, Elemi J; Williams, Nigel M; Hooper, Stephen R; Monfeuga, Thomas; Bassett, Anne S; Owen, Michael J; Gur, Raquel E; Morrow, Bernice E; McDonald-McGinn, Donna M; Swillen, Ann; Chow, Eva W C; van den Bree, Marianne; Emanuel, Beverly S; Vermeesch, Joris R; van Amelsvoort, Therese; Arango, Celso; Armando, Marco; Campbell, Linda E; Cubells, Joseph F; Eliez, Stephan; Garcia-Minaur, Sixto; Gothelf, Doron; Kates, Wendy R; Murphy, Kieran C; Murphy, Clodagh M; Murphy, Declan G; Philip, Nicole; Repetto, Gabriela M; Shashi, Vandana; Simon, Tony J; Suñer, Damiàn Heine; Vicari, Stefano; Scherer, Stephen W; Bearden, Carrie E; Vorstman, Jacob A S

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

淀粉样蛋白前体的细胞表达和蛋白水解加工与 TDP-43 无关

David A Hicks, Alys C Jones, Stuart M Pickering-Brown, Nigel M Hooper

Author Correction: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

作者更正:骨形态发生蛋白-1 对低密度脂蛋白受体的蛋白水解调节细胞胆固醇的吸收

Sreemoti Banerjee #, Robert J Andrew #, Christopher J Duff #, Kate Fisher, Carolyn D Jackson, Catherine B Lawrence, Nobuyo Maeda, Daniel S Greenspan, Katherine A B Kellett, Nigel M Hooper