日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis

NVL的小分子抑制剂通过阻断核糖体生物合成来抑制肿瘤生长。

Guo, Holly H; Tao, Ye; Cruz, Victor E; Fang, Min; Khivansara, Vishal; Xie, Shanhai; Leach, Ashley; Reddy, Divya; Peterson, Johann; Kim, Jiwoong; Williams, Noelle S; Aurora, Arin; Erzberger, Jan P; De Brabander, Jef K; Nijhawan, Deepak

Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells.

发现和优化靶向原发性胶质瘤干细胞样细胞的N-芳基化四环二甲酰亚胺

Wang Hua-Yu, Nguyen Thu P, Sternisha Alex C, Carroll Christopher L, Cross Bethany, Morlock Lorraine, Williams Noelle S, McBrayer Samuel, Nijhawan Deepak, De Brabander Jef K

Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.

烟酰胺的噻吩基衍生物通过 NAD 补救途径代谢为非天然 NAD 衍生物,这些衍生物抑制 IMPDH,对周围神经癌具有毒性

Theodoropoulos Panayotis C, Guo Holly H, Wang Wentian, Crossley Eric, Rivera Cancel Giomar, Fang Min, Nguyen Thu, Baniasadi Hamid, Williams Noelle S, Ready Joseph M, De Brabander Jef K, Nijhawan Deepak

A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins

药物化学驱动的方法确定甾醇异构酶 EBP 是 TASIN 结直肠癌毒素的分子靶点

Theodoropoulos, Panayotis C; Wang, Wentian; Budhipramono, Albert; Thompson, Bonne M; Madhusudhan, Nikhil; Mitsche, Matthew A; McDonald, Jeffrey G; De Brabander, Jef K; Nijhawan, Deepak

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

β-catenin驱动的癌症需要YAP1转录复合物才能存活和发生肿瘤。

Rosenbluh, Joseph; Nijhawan, Deepak; Cox, Andrew G; Li, Xingnan; Neal, James T; Schafer, Eric J; Zack, Travis I; Wang, Xiaoxing; Tsherniak, Aviad; Schinzel, Anna C; Shao, Diane D; Schumacher, Steven E; Weir, Barbara A; Vazquez, Francisca; Cowley, Glenn S; Root, David E; Mesirov, Jill P; Beroukhim, Rameen; Kuo, Calvin J; Goessling, Wolfram; Hahn, William C

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

紫外线照射后,Mcl-1的消除是启动细胞凋亡的必要条件。

Nijhawan, Deepak; Fang, Min; Traer, Elie; Zhong, Qing; Gao, Wenhua; Du, Fenghe; Wang, Xiaodong