Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile
在siRNA种子区对siRNA骨架进行单烷基膦酸酯修饰可增强其特异性和治疗效果。
期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf692
Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W Brad; Watt, Andrew T; Migawa, Michael T; Swayze, Eric E; Prakash, Thazha P