日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia

发现长效APOC3 siRNA用于治疗高甘油三酯血症患者

Prakash, Thazha P; Mullick, Adam E; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S; Klein, Stephanie; Swayze, Eric E

Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile

在siRNA种子区对siRNA骨架进行单烷基膦酸酯修饰可增强其特异性和治疗效果。

Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W Brad; Watt, Andrew T; Migawa, Michael T; Swayze, Eric E; Prakash, Thazha P

Tool to Resolve Distortions in Elemental and Isotopic Imaging

用于解决元素和同位素成像畸变问题的工具

Lu, Chixiang; Chen, Gu; Song, Wenxin; Chen, Kai; Hee, Charmaine; Nikan, Mehran; Guagliardo, Paul; Bennett, C Frank; Seth, Punit; Iyer, Killugudi Swaminathan; Young, Stephen G; Qi, Xiaojuan; Jiang, Haibo

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

合成和评价代谢稳定的 O-磷酸胆碱-N-二十二碳六烯酰-L-丝氨酸 siRNA 缀合物在小鼠脑中的实质保留和功效

Nikan Mehran, Osborn Maire F, Coles Andrew H, Biscans Annabelle, Godinho Bruno M D C, Haraszti Reka A, Sapp Ellen, Echeverria Dimas, DiFiglia Marian, Aronin Neil, Khvorova Anastasia

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

二十二碳六烯酸偶联可增强siRNA在小鼠脑内局部给药后的分布和安全性

Nikan, Mehran; Osborn, Maire F; Coles, Andrew H; Godinho, Bruno Mdc; Hall, Lauren M; Haraszti, Reka A; Hassler, Matthew R; Echeverria, Dimas; Aronin, Neil; Khvorova, Anastasia

An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes

乙炔桥联的6,8-嘌呤二聚体作为平行G-四链体的荧光开启探针

Nikan, Mehran; Di Antonio, Marco; Abecassis, Keren; McLuckie, Keith; Balasubramanian, Shankar

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

非经典DNA结构是转录因子SP1在体外的结合基序。

Raiber, Eun-Ang; Kranaster, Ramon; Lam, Enid; Nikan, Mehran; Balasubramanian, Shankar