日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation

RHOT蛋白将线粒体运动与心肌细胞肌节成熟联系起来

Froese, Natali; Shymotiuk, Ivanna; Froese, Alexander; Polten, Felix; Jablinski, Jonas; Scholz, Tim; Korf-Klingebiel, Mortimer; Werlein, Christopher; Galuppo, Paolo; Gigina, Anna; Wihler, Katharina; Schneider, Johanna; Erschow, Sergej; Heimerl, Maren; Szaroszyk, Malgorzata; Hegermann, Jan; Wrede, Christoph; Schweitzer, Theresa; Pich, Andreas; Geffers, Robert; Ricke-Hoch, Melanie; Kühnel, Mark P; Jonigk, Danny D; Wende, Adam R; Abel, E Dale; Nikolaev, Viacheslav O; Wollert, Kai C; Bauersachs, Johann; Riehle, Christian

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.

心肌细胞中 IRF3 的激活通过抑制 PGC-1α 损害线粒体氧化功能,从而导致心力衰竭。

Kumari Manju, Evangelakos Ioannis, Deshpande Anushka, De Jong Kirstie A, Schmiedel Nesrin, Palacio-Escat Nicolàs, Chaves-Filho Adriano de Britto, Frias-Soler Roberto Carlos, Klinke Glynis, Roh Hyun Cheol, Lange Luisa, Berlin Michael, Fuh Marceline M, Buss Jakob Johannes, Tian Tian, Lerchenmüller Carolin, Freichel Marc, Schulze Almut, Nikolaev Viacheslav O, Eschenhagen Thomas, Rosen Evan D, Scheja Ludger, Rangrez Ashraf Yusuf, Heeren Joerg, Frey Norbert

Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy.

激活 PRKG1 变体可增强平滑肌细胞变形能力,从而导致主动脉病变。

Jost Marie E, Schweizer Moyra, Henning Philipp, Gorzelanny Christian, Lehners Moritz, Ellinger Bernhard, Boix-Campos Javier, Kux Johan-Moritz, Singh Shubhangi, Fachinger Alexandra, Martinez Pomier Karla, VanSchouwen Bryan, Billing Anja M, Biedenweg Doreen, Schweizer Michaela, Siegel Saskia, Reimer Rudolph, Brandt Mona, Priesmeier Laura, Fuchs Ulrike, Pflaumenbaum Julia, Nikolaev Viacheslav O, Newbury-Ecob Ruth, Wilsdon Anna, Rybczynski Meike, Gehle Petra, Zelarayán Laura C, Stafforst Thorsten, Feil Robert, Rinschen Markus M, Pless Ole, Eaton Philip, Sáez Pablo J, Otto Oliver, Melacini Giuseppe, Demal Till J, Eschenhagen Thomas, Herberg Friedrich W, Cuello Friederike

Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome.

对一种引起严重炎症综合征的新型获得功能性 TLR8 变体进行结构建模和功能表征。

Skenteris Nikolaos T, Luttermann Elisa, Nair Sanjana, Evangelakos Ioannis, Pujantell Maria, Eggers Marie, Hausmann Fabian, Bérouti Marleen, Padoan Benedetta, Flomm Felix J, Claussen Janna M, Grünhagel Benjamin, Salfelder Anika, Beifuss Brigitte, Biskup Saskia, Blümke Patrick, Rading Katrin, Hildebrandt Heike, Matschl Urte, Giesemann-Jansen Silke, Hennesen Jana, Nikolaev Viacheslav O, Kutsche Michael, Kubisch Christian, Koch-Nolte Friedrich, Tomas Nicola M, Tolosa Eva, Lütgehetmann Marc, Stahl Felix R, Hornung Veit, Bunders Madeleine J, Schlein Christian, Topf Maya, Kötter Ina, Altfeld Marcus

Cyclic nucleotide phosphodiesterases as drug targets

环核苷酸磷酸二酯酶作为药物靶点

Kelly, Michy P; Nikolaev, Viacheslav O; Gobejishvili, Leila; Lugnier, Claire; Hesslinger, Christian; Nickolaus, Peter; Kass, David A; Pereira de Vasconcelos, Walma; Fischmeister, Rodolphe; Brocke, Stefan; Epstein, Paul M; Piazza, Gary A; Keeton, Adam B; Zhou, Gang; Abdel-Halim, Mohammad; Abadi, Ashraf H; Baillie, George S; Giembycz, Mark A; Bolger, Graeme; Snyder, Gretchen; Tasken, Kjetil; Saidu, Nathaniel E B; Schmidt, Martina; Zaccolo, Manuela; Schermuly, Ralph T; Ke, Hengming; Cote, Rick H; Mohammadi Jouabadi, Soroush; Roks, Anton J M

The role of compartmentalized β-AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes

区室化β-肾上腺素能受体/cAMP信号传导在白色和棕色脂肪细胞脂肪分解调控中的作用

De Jong, Kirstie A; Siddig, Sana; Pfeifer, Alexander; Nikolaev, Viacheslav O

Activated CaMKIIδ translocates to the RyR nanodomain in cardiomyocytes

活化的CaMKIIδ易位至心肌细胞中的RyR纳米结构域

Bergan-Dahl, Anna; Carlson, Cathrine R; Laasmaa, Martin; Subramanian, Hariharan; Basson, Adelle; Li, Jia; Hasic, Almira; Lunde, Marianne; Ugland, Hege; Manfra, Ornella; Klussmann, Enno; Bossuyt, Julie; Bers, Donald M; Nikolaev, Viacheslav O; Louch, William E; Shen, Xin

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles

环核苷酸的细胞间扩散以及随后的间隙连接关闭,重新启动了小鼠排卵前卵泡中的减数分裂。

Nakashima, Iris F; Zhong, Haining; Nikolaev, Viacheslav O; Owen, Corie M; Yee, Siu-Pok; Jaffe, Laurinda A; Egbert, Jeremy R

A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation

简述:磷酸二酯酶在T细胞活化过程中平衡细胞内cAMP的作用

Bielenberg, Marie; Kurelic, Roberta; Frantz, Stefan; Nikolaev, Viacheslav O

Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts

磷酸二酯酶 4B 和 4D 对小鼠心脏钙处理微区中的 cAMP 信号传导具有不同的调节作用

Kraft, Axel E; Bork, Nadja I; Subramanian, Hariharan; Pavlaki, Nikoleta; Failla, Antonio V; Zobiak, Bernd; Conti, Marco; Nikolaev, Viacheslav O