日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

首次通过荧光乙酰亚精胺脱乙酰化试验鉴定出与细胞靶标结合的选择性抑制剂

Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A Shinsky, Karin Schmidtkunz, Talha Z Yesiloglu, Theresa Bayer, Raphael R Steimbach, Corey J Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K Miller, David W Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung

Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6

N-(4-苯甲脒基)-噁唑烷酮的合成及构效关系:激肽释放酶相关肽酶 6 的强效和选择性抑制剂

Elena De Vita, Niels Smits, Helma van den Hurk, Elizabeth M Beck, Joanne Hewitt, Gemma Baillie, Emily Russell, Andrew Pannifer, Véronique Hamon, Angus Morrison, Stuart P McElroy, Philip Jones, Natalia A Ignatenko, Nikolas Gunkel, Aubry K Miller

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

二羟肟酸作为 HDAC6/8/10 抑制剂的设计和合成

Michael Morgen, Raphael R Steimbach, Magalie Géraldy, Lars Hellweg, Peter Sehr, Johannes Ridinger, Olaf Witt, Ina Oehme, Corey J Herbst-Gervasoni, Jeremy D Osko, Nicholas J Porter, David W Christianson, Nikolas Gunkel, Aubry K Miller

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated

组蛋白去乙酰化酶 10 的选择性抑制:与门控残基的氢键有关

Magalie Géraldy, Michael Morgen, Peter Sehr, Raphael R Steimbach, Davide Moi, Johannes Ridinger, Ina Oehme, Olaf Witt, Mona Malz, Mauro S Nogueira, Oliver Koch, Nikolas Gunkel, Aubry K Miller

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines

HDAC6/8/10 抑制剂 TH34 可诱导人类高级别神经母细胞瘤细胞系中 DNA 损伤介导的细胞死亡

Fiona R Kolbinger, Emily Koeneke, Johannes Ridinger, Tino Heimburg, Michael Müller, Theresa Bayer, Wolfgang Sippl, Manfred Jung, Nikolas Gunkel, Aubry K Miller, Frank Westermann, Olaf Witt, Ina Oehme

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

HDAC10 在溶酶体胞吐和 DNA 修复中的双重作用促进神经母细胞瘤化学耐药性

Johannes Ridinger, Emily Koeneke, Fiona R Kolbinger, Katharina Koerholz, Siavosh Mahboobi, Lars Hellweg, Nikolas Gunkel, Aubry K Miller, Heike Peterziel, Peter Schmezer, Anne Hamacher-Brady, Olaf Witt, Ina Oehme

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

醛脱氢酶 1 亚家族成员 2A 依赖性视黄酸信号传导受损与头颈部鳞状细胞癌的间质样表型和不良预后有关

Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon, Jochen Hess