日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

一种用于心脏保护和神经再生的PI3Kα小分子激活剂

Grace Q Gong ,Benoit Bilanges ,Ben Allsop ,Glenn R Masson ,Victoria Roberton ,Trevor Askwith ,Sally Oxenford ,Ralitsa R Madsen ,Sarah E Conduit ,Dom Bellini ,Martina Fitzek ,Matt Collier ,Osman Najam ,Zhenhe He ,Ben Wahab ,Stephen H McLaughlin ,A W Edith Chan ,Isabella Feierberg ,Andrew Madin ,Daniele Morelli ,Amandeep Bhamra ,Vanesa Vinciauskaite ,Karen E Anderson ,Silvia Surinova ,Nikos Pinotsis ,Elena Lopez-Guadamillas ,Matthew Wilcox ,Alice Hooper ,Chandni Patel ,Maria A Whitehead ,Tom D Bunney ,Len R Stephens ,Phillip T Hawkins ,Matilda Katan ,Derek M Yellon ,Sean M Davidson ,David M Smith ,James B Phillips ,Richard Angell ,Roger L Williams ,Bart Vanhaesebroeck

Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering

利用小角度 X 射线散射研究 β-冠状病毒非结构蛋白 10 刺激物的寡聚状态

Wolfgang Knecht, S Zoë Fisher, Jiaqi Lou, Céleste Sele, Shumeng Ma, Anna Andersson Rasmussen, Nikos Pinotsis, Frank Kozielski

Evasion of cGAS and TRIM5 defines pandemic HIV

逃避 cGAS 和 TRIM5 定义了 HIV 大流行

Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Gr

An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment

c-JUN N端磷酸化的内在时间顺序通过协调辅助因子募集来调节其活性

Christopher A Waudby #, Saul Alvarez-Teijeiro #, E Josue Ruiz #, Simon Suppinger, Nikos Pinotsis, Paul R Brown, Axel Behrens, John Christodoulou, Anastasia Mylona

Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening

基于片段的 X 射线筛选揭示 SARS-CoV-2 非结构蛋白 1 上的两个配体结合位点

Shumeng Ma, Shymaa Damfo, Jiaqi Lou, Nikos Pinotsis, Matthew W Bowler, Shozeb Haider, Frank Kozielski

Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila

WipA 蛋白的结构揭示了嗜肺军团菌的一种新型酪氨酸蛋白磷酸酶效应物

Nikos Pinotsis, Gabriel Waksman

The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery

军团菌效应物 WipB 是一种转位的丝氨酸/苏氨酸磷酸酶,靶向宿主溶酶体营养传感机制

Marie S Prevost, Nikos Pinotsis, Maud Dumoux, Richard D Hayward, Gabriel Waksman

The structure and regulation of human muscle α-actinin

人体肌肉α-辅肌动蛋白的结构和调控

Euripedes de Almeida Ribeiro Jr, Nikos Pinotsis, Andrea Ghisleni, Anita Salmazo, Petr V Konarev, Julius Kostan, Björn Sjöblom, Claudia Schreiner, Anton A Polyansky, Eirini A Gkougkoulia, Mark R Holt, Finn L Aachmann, Bojan Zagrović, Enrica Bordignon, Katharina F Pirker, Dmitri I Svergun, Mathias Gau

The binding of beta- and gamma-cyclodextrins to glycogen phosphorylase b: kinetic and crystallographic studies

β-和γ-环糊精与糖原磷酸化酶b的结合:动力学和晶体学研究

Nikos Pinotsis, Demetres D Leonidas, Evangelia D Chrysina, Nikos G Oikonomakos, Irene M Mavridis