日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum.

RAP蛋白调控恶性疟原虫顶质体非编码RNA的加工

Hollin Thomas, Chahine Zeinab, Abel Steven, Banks Charles, Pasaje Charisse Flerida A, Lenz Todd, Prudhomme Jacques, Ybanez Caitlyn Marie, Abbaszadeh Anahita S, Niles Jacquin C, Florens Laurence, Le Roch Karine G

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation

人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。

Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum

GeneTargeter:用于疟原虫(恶性疟原虫)基因组编辑的自动化计算机辅助设计

Cárdenas, Pablo; Esherick, Lisl Y; Chambonnier, Gaël; Dey, Sumanta; Turlo, Christopher V; Nasamu, Armiyaw Sebastian; Niles, Jacquin C