日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integration of palladium-catalyzed C-N coupling into self-encoded libraries for accelerated hit discovery

将钯催化CN偶联反应整合到自编码化合物库中,以加速先导化合物的发现。

van der Nol, Edith; Luo, Zhenshuo; Gao, Qing Qing; Haupt, Nils Alexander; Böcker, Sebastian; Pomplun, Sebastian

Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation

借助自动化小分子结构注释,实现从海量化合物库中无需条形码的先导化合物发现。

van der Nol, Edith; Haupt, Nils Alexander; Gao, Qing Qing; Smit, Benthe A M; Hoffmann, Martin Andre; Engler-Lukajewski, Martin; Ludwig, Marcus; McKenna, Sean; Mata, J Miguel; Béquignon, Olivier J M; van Westen, Gerard; Wendel, Tiemen J; Noordermeer, Sylvie M; Böcker, Sebastian; Pomplun, Sebastian

Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide

全D肽可直接将α-突触核蛋白预形成的纤维解离成α-突触核蛋白单体。

Sevenich, Marc; Gering, Ian; Kass, Bettina; Vollmer, Madita; Aghabashlou Saisan, Selma; Tusche, Markus; Kupreichyk, Tatsiana; Pauly, Thomas; Stoldt, Matthias; Hoyer, Wolfgang; Willuweit, Antje; Kutzsche, Janine; Lakomek, Nils-Alexander; Nagel-Steger, Luitgard; Gremer, Lothar; Tamgüney, Gültekin; Mohrlüder, Jeannine; Willbold, Dieter

Structural dynamics of the plant hormone receptor ETR1 in a native-like membrane environment

植物激素受体ETR1在类天然膜环境中的结构动力学

Lemke, Moritz; Lakomek, Nils Alexander; Groth, Georg

Vection underwater illustrates the limitations of neutral buoyancy as a microgravity analog

水下矢量运动说明了中性浮力作为微重力模拟的局限性

Bury, Nils-Alexander; Jenkin, Michael; Allison, Robert S; Herpers, Rainer; Harris, Laurence R

Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

通过三种不同的 NMR 技术监测低 pH 变性牛 PI3K-SH3 的淀粉样蛋白原纤维形成动力学

Luis Gardon #, Nina Becker #, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M Schulz, Kevin Bochinsky, Lothar Gremer, Henrike Heise, Nils-Alexander Lakomek

Effect of elevated irrigation bottle height during cataract surgery on corneal endothelial cells in porcine eyes

白内障手术中灌注瓶高度升高对猪眼角膜内皮细胞的影响

Wenzel, Daniel A; Schultheiss, Constanze; Druchkiv, Vasyl; Hellwinkel, Olaf J C; Spitzer, Martin S; Schultheiss, Maximilian; Casagrande, Maria; Steinhorst, Nils Alexander

Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein

噬菌体展示衍生化合物取代 hACE2 与 SARS-CoV-2 刺突蛋白的复合物

Marc Sevenich, Elena Thul, Nils-Alexander Lakomek, Thomas Klünemann, Maren Schubert, Federico Bertoglio, Joop van den Heuvel, Patrick Petzsch, Jeannine Mohrlüder, Dieter Willbold

Dimer Organization of Membrane-Associated NS5A of Hepatitis C Virus as Determined by Highly Sensitive (1) H-Detected Solid-State NMR

利用高灵敏度(1)H检测固态核磁共振技术测定丙型肝炎病毒膜相关NS5A的二聚体结构

Jirasko, Vlastimil; Lends, Alons; Lakomek, Nils-Alexander; Fogeron, Marie-Laure; Weber, Marco E; Malär, Alexander A; Penzel, Susanne; Bartenschlager, Ralf; Meier, Beat H; Böckmann, Anja

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

构象异质性与慢性精神疾病中涉及的支架蛋白的 β-原纤维形成

Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F Schröder, Dieter Willbold, Oliver H Weiergräber1